TPM3 and MAD1L1

  • Number of citations: 50 (PubMedID 32296183)
  • Data Source: BioGRID (two hybrid)

TPM3

MAD1L1

Name tropomyosin 3 mitotic arrest deficient 1 like 1
Structure PDB 6OTN PDB 1GO4
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs None
Diseases None
GWAS
  • Brain morphology (min-P) ( 32665545 )
  • Brain morphology (MOSTest) ( 32665545 )
  • Cooked vegetable consumption ( 32066663 )
  • Cortical surface area (min-P) ( 32665545 )
  • Cortical surface area (MOSTest) ( 32665545 )
  • Cortical thickness (min-P) ( 32665545 )
  • Cortical thickness (MOSTest) ( 32665545 )
  • Fish- and plant-related diet ( 32066663 )
  • High light scatter reticulocyte count ( 32888494 )
  • High light scatter reticulocyte percentage of red cells ( 32888494 )
  • Mean corpuscular hemoglobin ( 29403010 )
  • Mean corpuscular volume ( 29403010 32888494 )
  • Mean reticulocyte volume ( 32888494 )
  • Platelet count ( 27863252 )
  • Smoking initiation (ever regular vs never regular) ( 30679032 )
  • Subcortical volume (min-P) ( 32665545 )
  • Subcortical volume (MOSTest) ( 32665545 )
  • Adult body size ( 32376654 )
  • Adverse response to drug ( 30420678 )
  • Age at first birth ( 34211149 )
  • Age at first sexual intercourse ( 34211149 27089180 )
  • Alcohol consumption (drinks per week) ( 30643258 )
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 )
  • Anthropometric traits (multi-trait analysis) ( 30166351 )
  • Anxiety ( 31906708 )
  • Autism spectrum disorder or schizophrenia ( 28540026 )
  • Bipolar disorder ( 21926972 34002096 28115744 27329760 )
  • Bitter alcoholic beverage consumption ( 31046077 )
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 )
  • Coronary artery disease ( 29212778 33020668 )
  • Dimensional psychopathology (Social) ( 29496196 )
  • Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439 )
  • Gastroesophageal reflux disease ( 34187846 31527586 )
  • General factor of neuroticism ( 30867560 )
  • Gut microbiota relative abundance (Streptococcus) ( 33208821 )
  • Hand grip strength ( 29691431 )
  • Idiopathic pulmonary fibrosis ( 31710517 )
  • Longevity ( 20834067 )
  • Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269 )
  • Myocardial infarction ( 33532862 )
  • Number of sexual partners ( 30643258 )
  • Platelet count ( 32888494 )
  • Plateletcrit ( 32888494 )
  • Prostate cancer ( 29892016 )
  • Prostate cancer (advanced) ( 29892016 )
  • Refractive error ( 32231278 )
  • Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 )
  • Risk-taking tendency (4-domain principal component model) ( 30643258 )
  • Rosacea symptom severity ( 29771307 )
  • Schizophrenia ( 30285260 22688191 28991256 23974872 29483656 )
  • Schizophrenia or bipolar disorder ( 24280982 )
  • Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486 )
  • Sepsis (28-day mortality) ( 32592749 )
  • Sleep duration (short sleep) ( 30846698 )
  • Smoking initiation ( 33082346 )
  • Smoking status (ever vs never smokers) ( 30643258 )
  • Superior frontal gyrus volume ( 31530798 )
  • Superior temporal gyrus volume ( 31530798 )
  • Systolic blood pressure ( 30578418 )
  • Testicular germ cell tumor ( 28604732 23666239 28604728 )
  • Vaginal microbiome composition (Shannon diversity index) ( 32723796 )
Interacting Genes 60 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CAVIN3 CCDC102B CCDC146 CCHCR1 CHRM3 CNN1 DVL2 FAM9C FBXO5 FGA FNDC3B HDDC3 HOOK2 HSF2 HSF4 IFIT3 IKBIP ISG15 KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 MAST2 NEK2 NOD2 NUP54 ODAD1 OIP5 PBX3 PHLDB3 S100A2 S100A4 SMAD3 SNAPIN SUMO4 SYCE1 TAB2 TFPT THAP1 THAP7 TLK1 TMOD1 TMOD2 TNNI1 TNNT1 TRAP1 TRIM27 TRIP6 TSKS VPS52 WASH3P WASHC1 XIAP 63 interacting genes: ALOX5 AMOTL2 ATG5 BIRC2 CAPN7 CCDC57 CCHCR1 CDC37 CDK18 CIMIP4 COIL CWF19L2 DRC4 FAM131C FAM90A1 FXR1 GPKOW HAUS1 HDAC1 HDAC2 KIF9 LENG1 LGALSL LMO1 LMO3 LNX1 MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO NTAQ1 PIBF1 PML PPP1R18 PSMA1 RNF8 SIN3A SIN3B SPATA18 SPATA2 SUPT5H SYT17 SYT6 TCAF1 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSGA10 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32
Entrez ID 7170 8379
HPRD ID 01840 04065
Ensembl ID ENSG00000143549 ENSG00000002822
Uniprot IDs A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4G8 A0A0S2Z4I4 A0A2R2Y2Q3 B4DQ80 J3KN67 P06753 Q9Y6D9
PDB IDs 6OTN 1GO4 4DZO 7B1F 7B1H 7B1J
GO Terms Enriched among Interactors