TP53 and RRM2B

Number of citations: 0 (PubMedID 12615712)
Data Source: HPRD (in vivo)

		TP53	RRM2B
Name		tumor protein p53	ribonucleotide reductase regulatory TP53 inducible subunit M2B
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Replication Fork Transcription Regulator Complex Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Nuclear Matrix Nuclear Body PML Body Transcription Repressor Complex Protein-containing Complex Site Of Double-strand Break Germ Cell Nucleus	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ribonucleoside-diphosphate Reductase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protease Binding P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity MRNA 3'-UTR Binding Copper Ion Binding Protein Binding Zinc Ion Binding Enzyme Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Regulator Activity ATP-dependent DNA/DNA Annealing Activity Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding Protein Heterodimerization Activity Protein-folding Chaperone Binding Protein Phosphatase 2A Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding 14-3-3 Protein Binding MDM2/MDM4 Family Protein Binding Disordered Domain Specific Binding General Transcription Initiation Factor Binding Molecular Function Activator Activity Molecular Condensate Scaffold Activity Promoter-specific Chromatin Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitophagy In Utero Embryonic Development Somitogenesis Release Of Cytochrome C From Mitochondria Hematopoietic Progenitor Cell Differentiation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment T Cell Lineage Commitment Response To Ischemia Nucleotide-excision Repair Double-strand Break Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Autophagy Apoptotic Process DNA Damage Response Response To Oxidative Stress ER Overload Response Transforming Growth Factor Beta Receptor Signaling Pathway Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Gastrulation Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Central Nervous System Development Heart Development Circadian Rhythm Intracellular Protein Localization Negative Regulation Of DNA Replication Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Determination Of Adult Lifespan MRNA Transcription RRNA Transcription Response To Xenobiotic Stimulus Response To UV Response To Salt Stress Embryo Development Ending In Birth Or Egg Hatching Response To X-ray Response To Ionizing Radiation Response To Gamma Radiation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Programmed Cell Death Glial Cell Proliferation Viral Process Glucose Catabolic Process To Lactate Via Pyruvate Cerebellum Development Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Telomere Maintenance Via Telomerase T Cell Differentiation In Thymus Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Stress Regulation Of Tissue Remodeling Cellular Response To UV Multicellular Organism Growth Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Cell Population Proliferation Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Entrainment Of Circadian Clock By Photoperiod Mitochondrial DNA Repair Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Rhythmic Process Circadian Behavior Bone Marrow Development Embryonic Organ Development Protein Stabilization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Helicase Activity Protein Tetramerization Chromosome Organization Neuron Apoptotic Process Regulation Of Cell Cycle Hematopoietic Stem Cell Differentiation Negative Regulation Of Glial Cell Proliferation Type II Interferon-mediated Signaling Pathway Cardiac Septum Morphogenesis Positive Regulation Of Programmed Necrotic Cell Death Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Thymocyte Apoptotic Process Necroptotic Process Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-C Stem Cell Proliferation Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Reactive Oxygen Species Metabolic Process Cellular Response To Actinomycin D Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Senescence Replicative Senescence Oxidative Stress-induced Premature Senescence Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Oligodendrocyte Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Mitophagy Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of MiRNA Transcription Negative Regulation Of G1 To G0 Transition Negative Regulation Of MiRNA Processing Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Pentose-phosphate Shunt Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Stem Cell Proliferation Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	DNA Synthesis Involved In DNA Repair Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair DNA Damage Response Response To Oxidative Stress Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Amine Positive Regulation Of G0 To G1 Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 Association of TriC/CCT with target proteins during biosynthesis Pyroptosis TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription Regulation of PTEN gene transcription Loss of function of TP53 in cancer due to loss of tetramerization ability Signaling by ALK fusions and activated point mutants Regulation of NF-kappa B signaling Zygotic genome activation (ZGA) Factors involved in megakaryocyte development and platelet production PKR-mediated signaling	Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes
Drugs		Acetylsalicylic acid Zinc Triethyl phosphate AZD 3355 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Cladribine
Diseases		Chronic myeloid leukemia (CML) Breast cancer Non-small cell lung cancer Gastric cancer Adult T-cell leukemia Choriocarcinoma Esophageal cancer Glioma Pancreatic cancer Vulvar cancer Multiple myeloma Choroid plexus papilloma Ovarian cancer Hepatocellular carcinoma Squamous cell carcinoma Endometrial Cancer Penile cancer Cancer of the anal canal Hairy-cell leukemia Oral cancer Adrenal carcinoma Malignant melanoma Burkitt lymphoma Thyroid cancer Basal cell carcinoma Small cell lung cancer Gallbladder cancer Bladder cancer Laryngeal cancer Kaposi's sarcoma Cholangiocarcinoma Chronic lymphocytic leukemia (CLL) Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL) Malignant pleural mesothelioma Osteosarcoma Colorectal cancer	Mitochondrial DNA depletion syndrome (MDS)
GWAS		Appendicular lean mass ( 33097823 ) Basal cell carcinoma ( 24403052 25855136 21946351 27539887 31174203 33549134 ) Birth weight ( 31043758 ) Brain morphology (MOSTest) ( 32665545 ) Cancer ( 28346444 ) Cutaneous malignant melanoma ( 32341527 ) Diastolic blood pressure ( 28135244 27841878 30578418 ) Esophageal squamous cell carcinoma ( 25129146 ) Glioblastoma ( 28346443 29743610 ) Glioblastoma (age-stratified) ( 30152087 ) Glioma ( 28346443 29743610 ) Haemorrhoidal disease ( 33888516 ) Keratinocyte cancer (MTAG) ( 31174203 ) LDL cholesterol levels ( 32203549 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269 ) Nevus count or cutaneous melanoma ( 32341527 ) Non-glioblastoma glioma ( 29743610 28346443 ) Pulse pressure ( 28135244 30578418 27841878 ) Red blood cell count ( 32888494 ) Sex hormone levels ( 26014426 ) Sporadic neuroblastoma ( 28545128 ) Uterine fibroids ( 31649266 31249589 30194396 )	Blood protein levels ( 30072576 ) Chromosomal aberration frequency (total) ( 31586183 ) Chronic obstructive pulmonary disease ( 28166215 ) Mean corpuscular hemoglobin ( 29403010 ) Mean corpuscular volume ( 29403010 ) Red blood cell count ( 32888494 )
Interacting Genes		505 interacting genes: ABL1 ACKR3 ACTA1 AGT AKAP5 AKT1 ANK2 ANKRD2 ANTKMT ANXA3 APBB2 APEX1 APPL1 APTX ARAF ARID1A ARID3A ARIH2 ARL3 ARRB1 ATF3 ATM ATR ATXN3 AURKA BAG5 BAG6 BAIAP2L1 BAK1 BANP BARD1 BCAS3 BCL2 BCL2L1 BCL2L12 BCL2L2 BCL6 BCR BLM BMP1 BRCA1 BRCA2 BRF1 BTBD2 BTK C10orf90 CABLES1 CABLES2 CAPG CAPN1 CARM1 CBLC CBLL2 CCDC106 CCDC3 CCL18 CCNA2 CCNG1 CCNH CCT5 CD40LG CDC14A CDC14B CDC25C CDC42 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDKN2B CDKN2C CEBPA CEBPZ CENPX CETP CHD3 CHEK1 CHEK2 CHUK COP1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 COX17 CR2 CRBN CREBBP CREBZF CSNK1A1 CSNK1D CSNK2A1 CSNK2B CUL4A CUL7 CUL9 CXXC1 DAPK3 DAXX DAZAP2 DCAF1 DCST1 DDRGK1 DDX20 DDX5 DGKZ DHCR24 DHFR DLEU1 DMTF1 DNAJC7 DNMT3A DNMT3L DTL DVL2 E2F1 E4F1 EAF2 EEF2 EFEMP2 EGLN3 EGR1 EHMT1 EHMT2 EIF2AK2 EIF2S2 ELL ELL3 EP300 EPHA2 EPHA3 ERBB2 ERCC2 ERCC3 ERCC6 ERH ESR1 FBXO11 FCAMR FGFR4 FOS FOXO4 FXYD6 GADD45A GGA1 GGA2 GGA3 GNL3 GPS1 GPS2 GPX2 GRWD1 GSK3B GSTM4 GTF2H1 GTF2H4 GYS2 HABP4 HDAC1 HDAC2 HDAC3 HECTD3 HECW1 HEY1 HIF1A HINFP HIPK1 HIPK2 HMGA1 HMGA2 HMGB1 HMGB2 HNF4A HNRNPUL1 HSP90AA1 HSP90AB1 HSP90B1 HSPA1A HSPA9 HSPB1 HTT HUWE1 IFI16 IKBKB ING1 ING4 ING5 IRF7 ITPK1 JDP2 JUN KAT2A KAT2B KAT5 KAT7 KAT8 KDM1A KDM4C KDM4D KIAA0087 KLF4 KLF6 KMT5A KPNA2 KPNB1 LACTB LAMA4 LAMTOR5 LATS2 LDB3 MAD2L1BP MAGEA2 MAGEB18 MAML1 MAP2K3 MAP2K5 MAP3K1 MAPK1 MAPK10 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MDC1 MDH1 MDM2 MDM4 MED1 MED17 MED21 MEN1 MET MEX3A MIF MLF2 MNAT1 MNDA MPHOSPH6 MSL2 MSX1 MTA1 MTA2 MUC1 MUL1 MVP MYBBP1A MYC NABP1 NABP2 NAP1L1 NAT10 NCL NCOA1 NCOA2 NCOA3 NDN NEDD8 NEIL3 NF2 NFKBIA NFYA NFYB NGFR NMT1 NMT2 NOP53 NPM1 NQO1 NR0B2 NR3C1 NR4A1 NRON NSD2 NTHL1 OGT OTUB1 OTUD3 OTUD5 PADI1 PAFAH1B3 PARP1 PBK PCDHA4 PDGFRA PDLIM7 PELI1 PELI2 PELP1 PER2 PHB1 PIAS1 PIAS2 PIAS4 PIN1 PKM PLAGL1 PLCG2 PLK1 PLK3 PML PNP POLA1 PPA1 PPARGC1A PPIB PPM1D PPP1CA PPP1CC PPP1R13L PPP2CA PPP2R2B PPP4C PRIM1 PRKAB2 PRKCA PRKD1 PRKDC PRKN PRKRA PRMT1 PRPF8 PSMA3 PSMB3 PSMC5 PSMD11 PSMD4 PSME3 PTEN PTGS2 PTK2 PTTG1 RAB4A RAB7A RAD51 RAG1 RANBP9 RAP1B RBBP6 RBCK1 RBPJ RCHY1 RELA RING1 RNF125 RNF128 RNF138 RNF187 RNF38 RNF6 RPA1 RPA2 RPS6KA1 RPS6KA2 RPS6KA3 RRM2 RRM2B RSL1D1 RUNX3 S100A1 S100A2 S100A4 S100A6 S100A8 S100B SAT1 SCAMP1 SERPINB9 SETD7 SFN SHISA5 SIN3A SIN3B SIRT1 SIRT5 SLC9A9 SMAD2 SMAD3 SMARCA4 SMARCB1 SMARCD1 SMN1 SMYD2 SNRPN SOCS1 SP1 SP3 SRC SRSF1 SSBP1 SSTR3 STAMBP STARD10 STAT6 STK11 STK4 STUB1 STX5 SUB1 SULT1E1 SUMO1 SYVN1 TADA3 TAF1 TAF1A TAF1B TAF1C TAF9 TAF9B TBP TCF4 TEAD2 TEC TEP1 TFAP2A TFAP2C TFDP1 TFIP11 THAP12 THAP8 THRB TK1 TOP1 TOP1MT TOP2A TOP2B TOPORS TP53BP1 TP53BP2 TP53INP1 TP53RK TP63 TP73 TRIAP1 TRIM21 TRIM39 TRIM41 TRIM65 TRIM67 TSC22D1 TSG101 TTK TWIST1 TXN UBB UBE2A UBE2D2 UBE2I UBE2K UBE2L3 UBE2M UBE2N UBE2Q1 UBE2V2 UBE3A UBE4B UFD1 UFL1 UHRF1 UHRF2 UIMC1 USP19 USP21 USP24 USP28 USP3 USP42 USP49 USP7 UTP14A VRK1 WDR33 WDR5 WDR82 WRN WT1 WWOX WWP1 XAF1 XPO1 XRCC6 YBX1 YWHAG YWHAZ YY1 YY2 ZBTB49 ZBTB5 ZCCHC10 ZHX1 ZIC3 ZMIZ2 ZNF148 ZNF24 ZNF302 ZNF679 ZNF839 ZNHIT1	9 interacting genes: CDKN1A CSNK2A1 MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53
Entrez ID		7157	50484
HPRD ID		01859	05276
Ensembl ID		ENSG00000141510	ENSG00000048392
Uniprot IDs		A0A087WT22 A0A087WXZ1 A0A087X1Q1 H2EHT1 K7PPA8 P04637 Q53GA5	Q7LG56
PDB IDs		1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YC5 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2F1X 2FEJ 2FOJ 2FOO 2GS0 2H1L 2H2D 2H2F 2H4F 2H4H 2H4J 2H59 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 2J21 2K8F 2L14 2LY4 2MEJ 2MWO 2MWP 2MWY 2MZD 2OCJ 2PCX 2RUK 2VUK 2WGX 2X0U 2X0V 2X0W 2XWR 2YBG 2YDR 2Z5S 2Z5T 3D05 3D06 3D07 3D08 3D09 3D0A 3DAB 3DAC 3IGK 3IGL 3KMD 3KZ8 3LW1 3OQ5 3PDH 3Q01 3Q05 3Q06 3SAK 3TG5 3TS8 3ZME 4AGL 4AGM 4AGN 4AGO 4AGP 4AGQ 4BUZ 4BV2 4HFZ 4HJE 4IBQ 4IBS 4IBT 4IBU 4IBV 4IBW 4IBY 4IBZ 4IJT 4KVP 4LO9 4LOE 4LOF 4MZI 4MZR 4QO1 4RP6 4RP7 4X34 4XR8 4ZZJ 5A7B 5AB9 5ABA 5AOI 5AOJ 5AOK 5AOL 5AOM 5BUA 5ECG 5G4M 5G4N 5G4O 5HOU 5HP0 5HPD 5LAP 5LGY 5MCT 5MCU 5MCV 5MCW 5MF7 5MG7 5MHC 5MOC 5O1A 5O1B 5O1C 5O1D 5O1E 5O1F 5O1G 5O1H 5O1I 5OL0 5UN8 5XZC 6FF9 6FJ5 6GGA 6GGB 6GGC 6GGD 6GGE 6GGF 6LHD 6R5L 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RWH 6RWI 6RWS 6RWU 6RX2 6RZ3 6S39 6S3C 6S40 6S9Q 6SHZ 6SI0 6SI1 6SI2 6SI3 6SI4 6SIN 6SIO 6SIP 6SIQ 6SL6 6SLV 6T58 6V4F 6V4H 6VQO 6VR1 6VR5 6VRM 6VRN 6W51 6XRE 6ZNC 7B46 7B47 7B48 7B49 7B4A 7B4B 7B4C 7B4D 7B4E 7B4F 7B4G 7B4H 7B4N 7BWN 7DHY 7DHZ 7DVD 7EAX 7EDS 7EEU 7EL4 7NMI 7RM4 7V97 7XZX 7XZZ 7YGI 8A31 8A32 8A92 8CG7 8DC4 8DC6 8DC7 8DC8 8E7A 8E7B 8GCR 8HLL 8HLM 8HLN 8J8N 8OXM 8OXO 8QWK 8QWL 8QWM 8QWN 8QWO 8QWP 8R1F 8R1G 8RBA 8RBB 8RBC 8RCI 8UQR 8WD2 8XP5 9BR4 9C5S 9CHT	2VUX 3HF1 4DJN
GO Terms Enriched among Interactors		Nucleoplasm Nucleus Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Cellular Response To Stress Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription DNA Damage Response Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Intracellular Signal Transduction DNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Protein Metabolic Process P53 Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Metabolic Process Regulation Of Cellular Response To Stress Post-translational Protein Modification Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Chromatin Organization Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Chromatin Remodeling Negative Regulation Of RNA Biosynthetic Process DNA Repair Response To Stress Negative Regulation Of RNA Metabolic Process Transferase Activity Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Gamma Radiation Disordered Domain Specific Binding Regulation Of Cell Cycle Process Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Cellular Response To Actinomycin D Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Response To Actinomycin D DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Gamma Radiation Regulation Of Mitotic Cell Cycle Cellular Response To UV-C Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Reactive Oxygen Species Metabolic Process Stress-induced Premature Senescence Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Antibiotic Protein-containing Complex Assembly Protein Tetramerization Signal Transduction By P53 Class Mediator DNA Damage Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Mitophagy Cellular Response To Light Stimulus Protein-containing Complex Organization DNA Damage Response Response To UV-C Replicative Senescence Positive Regulation Of Cell Cycle Phase Transition 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization Mitotic G1 DNA Damage Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Cytosol Regulation Of Signal Transduction By P53 Class Mediator Cellular Component Assembly Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process