TOP2A and SRPK1

Number of citations: 0 (PubMedID 15034300)
Data Source: HPRD (in vivo)

		TOP2A	SRPK1
Name		DNA topoisomerase II alpha	SRSF protein kinase 1
Structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Male Germ Cell Nucleus Nucleus Nucleoplasm Nucleolus Cytoplasm Centriole DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Protein-containing Complex Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Nuclear Matrix Nuclear Speck
	Molecular Function	Nucleotide Binding Magnesium Ion Binding DNA Binding Chromatin Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA DNA Binding, Bending Isomerase Activity Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Protein Heterodimerization Activity	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Metabolic Process DNA Topological Change Chromatin Organization DNA Damage Response Chromosome Segregation Female Meiotic Nuclear Division Chromosome Condensation Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process	Spliceosomal Complex Assembly MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Cell Differentiation Sperm DNA Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing
Pathways		Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins	Maturation of nucleoprotein Replacement of protamines by nucleosomes in the male pronucleus
Drugs		Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Dactinomycin Lomefloxacin Doxorubicin Norfloxacin Norfloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone Banoxantrone SP1049C Amonafide Elsamitrucin 13-deoxydoxorubicin RTA 744 Aldoxorubicin ZEN-012 Amrubicin Becatecarin Annamycin Declopramide Finafloxacin	None
GWAS		Appendicular lean mass ( 33097823 ) Hip circumference ( 25673412 ) Hip circumference adjusted for BMI ( 25673412 ) Neutrophil percentage of white cells ( 32888494 )	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 )
Interacting Genes		36 interacting genes: ATM BRCA1 CDK1 CEBPA COPS5 CSNK2A1 DFFB DHX9 FBXO28 GINS1 HDAC1 HDAC2 HNRNPD JUN MAPK1 MDM4 PIAS4 PIN1 PLK1 PRKCA PRKCB PRKCG RB1 RNF10 RNF168 SMURF2 SRPK1 SUMO1 SUMO2 SUMO4 TOP2B TP53 UBE2I USP7 XPO1 YWHAE	167 interacting genes: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARK2N ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf87 C16orf78 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CIMAP1D CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG JHY KCNAB1 KCNN2 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L3 MACROH2A1 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MAPT MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBMS2 RIMS4 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SANBR SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRRM1 SRSF1 SRSF10 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP7 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2
Entrez ID		7153	6732
HPRD ID		00536	15992
Ensembl ID		ENSG00000131747	ENSG00000096063
Uniprot IDs		P11388	Q96SB4
PDB IDs		1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE 6ZY5 6ZY6 6ZY7 6ZY8 8W50	1WAK 1WBP 3BEG 4WUA 5MXX 5MY8 5NNG 5XV7 6FAD 7DD1 7PQS 7ZKS
GO Terms Enriched among Interactors		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Modification Process Regulation Of RNA Biosynthetic Process Nucleoplasm Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of RNA Metabolic Process PML Body Regulation Of Cell Cycle DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Signal Transduction In Response To DNA Damage Regulation Of DNA Repair DNA Damage Checkpoint Signaling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Rhythmic Process Presynaptic Cytosol Regulation Of Protein Catabolic Process Postsynaptic Cytosol Regulation Of Proteolysis Mitotic Nuclear Membrane Disassembly Chromatin Organization Regulation Of Proteasomal Protein Catabolic Process	RNA Splicing Regulation Of MRNA Processing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Nucleoplasm Nucleus MRNA Binding Nuclear Speck Nucleic Acid Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleic Acid Binding Protein Kinase Activity Negative Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Kinase Activity Negative Regulation Of RNA Splicing Spliceosomal Complex Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Protein-RNA Complex Assembly Pre-mRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Alternative MRNA Splicing, Via Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific MRNA Binding Main Axon Response To Starvation Regulation Of Toll Signaling Pathway Catalytic Step 2 Spliceosome Protein Autophosphorylation IkappaB Kinase Complex Positive Regulation Of Viral Process Protein Phosphorylation Positive Regulation Of RNA Splicing