TMSB4X and TGM2

Number of citations: 0 (PubMedID 10611475)
Data Source: HPRD (in vivo)

		TMSB4X	TGM2
Name		thymosin beta 4 X-linked	transglutaminase 2
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Platelet Alpha Granule Lumen	Chromatin Nucleosome Extracellular Region Nucleus Chromosome Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Binding Actin Binding Actin Monomer Binding Actin Monomer Sequestering Activity Protein Binding Enzyme Binding Protein Sequestering Activity	Nucleotide Binding Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Metal Ion Binding Protein-glutamine Glutaminase Activity Peptide Serotonyltransferase Activity Histone Serotonyltransferase Activity Peptide Dopaminyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity
	Biological Process	Actin Filament Organization Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Inflammatory Response Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proton-transporting ATP Synthase Activity, Rotational Mechanism Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of ATP Biosynthetic Process	Chromatin Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Gene Expression Dopamine Secretion Peptide Cross-linking Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Positive Regulation Of Sprouting Angiogenesis Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance
Pathways		Platelet degranulation	None
Drugs		None	Guanosine-5'-Diphosphate Hexylresorcinol
GWAS		Asthma ( 30929738 ) Asthma (childhood onset) ( 30929738 )	No GWAS studies recorded
Interacting Genes		38 interacting genes: ACTA1 ACTA2 ACTB ACTG1 AKAP8L ALAS1 ANXA7 APLP1 CDKN1A COG6 FAM118B FHL3 GOLGA6L9 GRB7 HSF2BP IGSF21 ILK KRT13 KRT15 KRT31 KRT34 KRT36 KRT40 KRTAP8-1 LIMS1 PNMA1 PPP4C RAD21 RBPMS SCHIP1 SMN1 TAF1D TGM2 TK1 TRIM23 TRIM27 TRIP6 UHMK1	72 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 COL11A1 COL18A1 COL1A1 COL4A1 COL6A1 CSNK2A2 EIF5A FN1 FNDC3B FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HMGB1 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGAV ITGB1 ITGB3 KPNA3 KPNA4 LACRT LAMA1 LTBP1 MAP3K12 MMP14 PAK1 PELI2 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SNCA SPARC TAB2 THBS1 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		7114	7052
HPRD ID		02153	01825
Ensembl ID		ENSG00000205542	ENSG00000198959
Uniprot IDs		A2VCK8 P62328 Q0P5T0	B4DIT7 B4DTN7 P21980
PDB IDs		3TU5 4PL7 4PL8	1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB 8TR9 9BC2 9BC3 9BC4
GO Terms Enriched among Interactors		Morphogenesis Of An Epithelium Structural Constituent Of Skin Epidermis Tissue Morphogenesis Intermediate Filament Organization Intermediate Filament Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoskeleton Epithelial Cell Differentiation Structural Constituent Of Cytoskeleton Cytosol Structural Molecule Activity Focal Adhesion Supramolecular Fiber Organization Regulation Of Transepithelial Transport Stress Fiber Cytoskeleton Organization Mesenchyme Migration Dense Body Protein Kinase Binding Identical Protein Binding Developmental Process Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Platelet Aggregation Organelle Organization Anatomical Structure Morphogenesis Epidermis Development Actin Cytoskeleton Homotypic Cell-cell Adhesion Postsynaptic Actin Cytoskeleton Organization Cellular Response To Catecholamine Stimulus Lamellipodium Protein Localization To Cell-cell Junction Calyx Of Held Response To Catecholamine Actin Filament Postsynaptic Cytoskeleton Organization Protein Binding Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Hepatic Stellate Cell Contraction Apical Junction Complex NuA4 Histone Acetyltransferase Complex Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Basal Body Patch Alpha-2B Adrenergic Receptor Binding Peptide Dopaminyltransferase Activity	Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Oxidative Stress Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Protease Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Extracellular Matrix Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Differentiation Regulation Of Cell Migration Signal Transduction Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Extracellular Space Regulation Of Cell Motility Regulation Of Defense Response Apolipoprotein A-I-mediated Signaling Pathway Response To Reactive Oxygen Species C3HC4-type RING Finger Domain Binding Response To External Biotic Stimulus Blood Microparticle Positive Regulation Of Cell Differentiation Focal Adhesion Regulation Of Immune System Process Response To Lipid Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Response To Hormone Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Extracellular Region Regulation Of Apoptotic Signaling Pathway Enzyme Binding Regulation Of Phosphorus Metabolic Process