THBD and PROC

Number of citations: 74 (PubMedID 11106601)
Data Source: HPRD (in vitro)

		THBD	PROC
Name		thrombomodulin	protein C, inactivator of coagulation factors Va and VIIIa
Structure
GO Annotations	Cellular Component	Extracellular Space Vacuolar Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Apicolateral Plasma Membrane Serine-type Endopeptidase Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding Signaling Receptor Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Female Pregnancy Blood Coagulation Hemostasis Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Zymogen Activation Response To Lipopolysaccharide Negative Regulation Of Coagulation Response To CAMP Negative Regulation Of Fibrinolysis Blood Coagulation, Common Pathway	Proteolysis Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Drotrecogin alfa Ibuprofen Dexibuprofen	Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human
Diseases		Inherited thrombophilia	Inherited thrombophilia
GWAS		Blood protein levels in cardiovascular risk ( 28369058 ) Lung function (FVC) in asthma ( 32989782 ) PR interval in Tripanosoma cruzi seropositivity ( 24324551 ) Venous thromboembolism ( 26888256 )	Blood protein levels ( 30072576 ) Protein C levels ( 20802025 25376901 28082259 )
Interacting Genes		33 interacting genes: AIG1 APOC2 APOC4 AQP6 CD79A CIDEB CYBC1 EBP ERGIC3 F2 FAM209A FCER1G GPR152 GPX8 KIR2DL3 LMNA MMGT1 MTIF3 MUC1 PDZK1IP1 PF4 PHF24 PROC PSENEN RHBDD2 SERPINA5 SLC10A6 SLC19A3 SLC35H1 TMEM14B TMEM35A TMEM86B TMX2	15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		7056	5624
HPRD ID		01764	01466
Ensembl ID		ENSG00000178726	ENSG00000115718
Uniprot IDs		P07204	B4DPC8 B4DPQ3 E7END6 P04070
PDB IDs		1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS 5TO3 7T4R	1AUT 1LQV 3F6U 3JTC 4DT7 6M3B 6M3C 8JRU 8JRV 9BVM
GO Terms Enriched among Interactors		Membrane Endoplasmic Reticulum Membrane Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Lipid Transport Protein Binding Organic Hydroxy Compound Transport Identical Protein Binding Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Endoplasmic Reticulum Positive Regulation Of Protein Localization To Cell Surface Very-low-density Lipoprotein Particle	Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Negative Regulation Of Coagulation Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Platelet Alpha Granule Lumen Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Region Biological Process Involved In Interaction With Symbiont Endoplasmic Reticulum Lumen Regulation Of Wound Healing Copper Ion Binding Regulation Of Response To Wounding Extracellular Exosome Negative Regulation Of Fibrinolysis Golgi Lumen Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Fibrinolysis Platelet Alpha Granule Protease Binding Protein Activation Cascade Blood Microparticle Protein Maturation Positive Regulation Of Blood Coagulation Regulation Of Biological Quality Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Heparin Binding Extracellular Matrix Negative Regulation Of Multicellular Organismal Process COPII-coated ER To Golgi Transport Vesicle Zymogen Activation Acute-phase Response Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Gamma-glutamyl Carboxylase Activity Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex