TRD and CD3G

Number of citations: 64 (PubMedID 2547833)
Data Source: HPRD (in vivo)

		TRD	CD3G
Name		T cell receptor delta locus	CD3 gamma subunit of T-cell receptor complex
Structure		No pdb structure
GO Annotations	Cellular Component	None	Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex
	Molecular Function	None	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding
	Biological Process	None	Adaptive Immune Response Immune System Process Establishment Or Maintenance Of Cell Polarity Cell Surface Receptor Signaling Pathway Protein Transport T Cell Activation Positive Thymic T Cell Selection Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Regulation Of Lymphocyte Apoptotic Process
Pathways		None	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Co-inhibition by PD-1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		None	Muromonab Teclistamab Odronextamab
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		4 interacting genes: CD3G TRA TRB TRG	14 interacting genes: CATSPERH CD3D CD3E EMP1 KTN1 LAT MAL PMP22 TMEM19 TMEM203 TMEM54 TRA TRB TRD
Entrez ID		6964	917
HPRD ID		01731	07037
Ensembl ID		Not available	ENSG00000160654
Uniprot IDs		Not available	B0YIY5 P09693
PDB IDs		Not available	1SY6 6JXR 7FJD 7FJE 7FJF 7PHR 7Q5U 8ES7 8ES8 8ES9 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
GO Terms Enriched among Interactors		Alpha-beta T Cell Receptor Complex Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response To Tumor Cell T Cell Mediated Cytotoxicity T Cell Receptor Complex Adaptive Immune Response Detection Of Biotic Stimulus T Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Gamma-delta T Cell Receptor Complex Cell Killing Immune Response Detection Of Stimulus Signaling Receptor Activity Positive Thymic T Cell Selection T Cell Receptor Binding Immune Effector Process Positive T Cell Selection Thymic T Cell Selection Immune System Process Gamma-delta T Cell Activation T Cell Selection Signaling Receptor Complex Adaptor Activity Regulation Of Lymphocyte Apoptotic Process Clathrin-coated Endocytic Vesicle Membrane	Alpha-beta T Cell Receptor Complex T Cell Receptor Complex Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Adaptive Immune Response Membrane Raft Distribution Immune Response To Tumor Cell Membrane Raft Localization Membrane Bleb Assembly Positive Thymic T Cell Selection Positive T Cell Selection T Cell Receptor Signaling Pathway T Cell Mediated Cytotoxicity Thymic T Cell Selection Plasma Membrane Antigen Receptor-mediated Signaling Pathway T Cell Selection Membrane Raft Organization Detection Of Biotic Stimulus Signaling Receptor Complex Adaptor Activity T Cell Mediated Immunity Immunological Synapse Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production TCR Signalosome Leukocyte Mediated Cytotoxicity T Cell Activation Gamma-delta T Cell Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway Membrane Raft Polarization Immune Response Immune Response-activating Signaling Pathway Alpha-beta T Cell Activation T Cell Anergy Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Protein Localization To Paranode Region Of Axon Myelination Axon Ensheathment Compact Myelin