TCP1 and TUBA8

Number of citations: 47 (PubMedID 9885248)
Data Source: HPRD (in vivo)

		TCP1	TUBA8
Name		t-complex 1	tubulin alpha 8
Structure			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Heterochromatin Acrosomal Vesicle Zona Pellucida Receptor Complex Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome Intracellular Protein-containing Complex	Acrosomal Vesicle Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Protein Folding Tubulin Complex Assembly Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization ScaRNA Localization To Cajal Body Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Spermatogenesis Spermatid Development
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Cargo trafficking to the periciliary membrane RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		None	Epothilone D Patupilone
GWAS		No GWAS studies recorded	Atrial fibrillation ( 29892015 30061737 ) Cerebrospinal T-tau levels ( 28247064 )
Interacting Genes		18 interacting genes: ANXA1 CBFA2T2 CCT5 CCT7 CDC20 CEBPA DUX4 FANCA OGT PDCL PTEN SH3BP4 SLC26A4-AS1 SUMO2 TUBA4A TUBA8 VRK2 YWHAQ	8 interacting genes: FOXP1 GRM7 LINC01554 MYC PXN SIAH1 TCP1 TCP11L2
Entrez ID		6950	51807
HPRD ID		01748	05763
Ensembl ID		ENSG00000120438	ENSG00000183785
Uniprot IDs		E7EQR6 P17987	Q9NY65
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT	Not available
GO Terms Enriched among Interactors		Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex Binding Regulation Of Proteolysis Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Ligase Activator Activity Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Microtubule Negative Regulation Of Cell Cycle Binding Of Sperm To Zona Pellucida Regulation Of Protein Catabolic Process ATP-dependent Protein Folding Chaperone Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Protein-containing Complex Metaphase/anaphase Transition Of Meiosis I RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Heterotrimeric G-protein Complex Assembly Negative Regulation Of Synaptic Vesicle Clustering Organelle Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Sperm-egg Recognition Microtubule Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Organelle Organization Cytoplasm Protein Domain Specific Binding Protein Localization To Lysosome Cell-cell Recognition Protein Folding Chaperone Regulation Of Cellular Component Organization Regulation Of Chromosome Organization Response To Vitamin B2 C/EBP Complex	Chaperonin-containing T-complex Core Promoter Sequence-specific DNA Binding Regulation Of Monocyte Differentiation Regulation Of B Cell Apoptotic Process ATP-dependent Protein Folding Chaperone Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Telomere Maintenance Group III Metabotropic Glutamate Receptor Activity Myc-Max Complex Regulation Of Acinar Cell Proliferation Positive Regulation Of Interleukin-21 Production