BTK and JAK1

Number of citations: 0 (PubMedID 9178903)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		BTK	JAK1
Name		Bruton tyrosine kinase	Janus kinase 1
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Lipid Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Identical Protein Binding Phospholipase Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding CCR5 Chemokine Receptor Binding Metal Ion Binding
	Biological Process	Neutrophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Cytokine Production Adaptive Immune Response B Cell Affinity Maturation Immune System Process Histamine Secretion By Mast Cell Positive Regulation Of Immunoglobulin Production Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Apoptotic Process Mesoderm Development Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Proteoglycan Catabolic Process Negative Regulation Of B Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of B Cell Differentiation Cell Maturation Positive Regulation Of Phagocytosis T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Monocyte Proliferation Negative Regulation Of Leukocyte Proliferation Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway Cellular Response To Interleukin-7 CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Interleukin-17A Production Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Synoviocyte Proliferation Eosinophil Homeostasis	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Intracellular Signal Transduction Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Response To Antibiotic Regulation Of Multicellular Organismal Process Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Virus Cellular Response To Interleukin-7 Interleukin-10-mediated Signaling Pathway Protein Localization To Cell-cell Junction Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Sprouting Angiogenesis
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization G alpha (q) signalling events G alpha (12/13) signalling events MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate WASPs and WAVEs G beta:gamma signalling through BTK FCGR3A-mediated phagocytosis Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation ISG15 antiviral mechanism Interleukin-7 signaling Interleukin-7 signaling Other interleukin signaling RAF/MAP kinase cascade Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-2 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-27 signaling Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses IFNG signaling activates MAPKs Evasion by RSV of host interferon responses PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs		Dasatinib Inositol 1,3,4,5-Tetrakisphosphate XL418 Ibrutinib Acalabrutinib Spebrutinib Fostamatinib Fenebrutinib Zanubrutinib Evobrutinib Tirabrutinib Abivertinib Branebrutinib Vecabrutinib	Myricetin 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Ruxolitinib Tofacitinib Baricitinib Fostamatinib Fedratinib Filgotinib Abrocitinib Upadacitinib Pralsetinib Ivarmacitinib
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD) Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8	None
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Autoimmune thyroid disease ( 32581359 ) Bevacizumab-induced proteinuria ( 34616010 ) Cognitive function in longevity ( 33607172 ) Core binding factor acute myeloid leukemia ( 27903959 ) Eosinophil count ( 32888494 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Medication use (thyroid preparations) ( 31015401 ) Monocyte percentage of white cells ( 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of granulocytes ( 27863252 ) Plasma anti-thyroglobulin levels ( 29678681 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Sum eosinophil basophil counts ( 27863252 )
Interacting Genes		77 interacting genes: ABL1 APP AR ARHGAP17 ARID3A ARRB1 AURKA BCL2L11 BECN1 BLNK BMX CAV1 CBL CD19 CMTM3 COASY CPVL DAPP1 ERBB3 EWSR1 FAS FASLG FYN GAB1 GNA12 GNAQ GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MDM2 MEOX2 MET MRPS22 MYD88 PIK3AP1 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 SMURF1 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TP53 VAV1 WAS WASF2	77 interacting genes: ABL1 AGTR1 BRCA1 BTK CCR1 CCR5 CISH CSF2RB CSF3R CXCR4 EIF2AK2 ELP2 ERBB2 FER FES GAB1 GHR GRB2 H3-4 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK2 JAK3 JAKMIP1 MDK OSMR PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RACK1 RAF1 SH2B2 SHB SOCS1 SOCS2 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 STUB1 SYK TEC TNFRSF1A TOP1 TSHR TTC3 TYK2 USP6
Entrez ID		695	3716
HPRD ID		02248	00992
Ensembl ID		ENSG00000010671	ENSG00000162434
Uniprot IDs		Q06187 Q5JY90	A0A8V8TPQ9 P23458 Q6P669
PDB IDs		1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3 4NWM 4OT5 4OT6 4OTF 4OTQ 4OTR 4RFY 4RFZ 4RG0 4RX5 4YHF 4Z3V 4ZLY 4ZLZ 5BPY 5BQ0 5FBN 5FBO 5J87 5JRS 5KUP 5P9F 5P9G 5P9H 5P9I 5P9J 5P9K 5P9L 5P9M 5T18 5U9D 5VFI 5VGO 5XYZ 5ZZ4 6AUA 6AUB 6BIK 6BKE 6BKH 6BKW 6BLN 6DI0 6DI1 6DI3 6DI5 6DI9 6E4F 6EP9 6HRP 6HRT 6HTF 6J6M 6N9P 6NFH 6NFI 6NZM 6O8I 6OMU 6S90 6TFP 6TSE 6TT2 6TUH 6TVN 6VXQ 6W06 6W07 6W7O 6W8I 6X3N 6X3O 6X3P 6XE4 6YYF 6YYG 6YYK 7KXL 7KXM 7KXN 7KXO 7KXP 7KXQ 7L5O 7L5P 7LTY 7LTZ 7N4Q 7N4R 7N4S 7N5O 7N5R 7N5X 7N5Y 7R60 7R61 7YC9 8DSO 8E2M 8EJB 8FLG 8FLH 8FLL 8FLN 8FLV 8GC7 8GC8 8TU3 8TU4 8TU5 8U2D 8U2E 8YVV	3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04 5WO4 6AAH 6BBU 6C7Y 6DBN 6ELR 6GGH 6HZU 6N77 6N78 6N79 6N7A 6N7B 6N7C 6N7D 6RSB 6RSC 6RSD 6RSE 6RSH 6SM8 6SMB 6TPE 6TPF 6W8L 8EXJ 8S85
GO Terms Enriched among Interactors		Immune Response-regulating Signaling Pathway Signal Transduction Immune Response-activating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Positive Regulation Of Immune Response Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Immune System Process Regulation Of Immune Response Kinase Activity Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Immune System Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Immune System Process Positive Regulation Of Signal Transduction Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cellular Component Organization Positive Regulation Of Innate Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Protein Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Fc Receptor Signaling Pathway Intracellular Signaling Cassette Leukocyte Activation Cytoplasm Antigen Receptor-mediated Signaling Pathway Regulation Of Innate Immune Response Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Cell Activation Regulation Of Programmed Cell Death Positive Regulation Of Defense Response Positive Regulation Of Metabolic Process Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Cell Surface Pattern Recognition Receptor Signaling Pathway Response To Lipid Positive Regulation Of Canonical NF-kappaB Signal Transduction	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Cytokine Receptor Activity Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Population Proliferation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Hemopoiesis Regulation Of Cell Differentiation Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Activation Regulation Of Cell Development Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Immune System Process Cell Activation Receptor Complex Positive Regulation Of Signal Transduction Plasma Membrane Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication External Side Of Plasma Membrane Regulation Of Lymphocyte Differentiation Regulation Of Multicellular Organismal Development Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Phosphorylation Leukocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Regulation Of T Cell Activation Protein Phosphorylation Lymphocyte Activation Regulation Of Cell Adhesion