HNF1A and RNF14

Number of citations: 22 (PubMedID 23449499)
Data Source: BioGRID (affinity chromatography technology, pull down)

		HNF1A	RNF14
Name		HNF1 homeobox A	ring finger protein 14
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Protein-containing Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytosolic Ribosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Nuclear Androgen Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Liver Development Regulation Of Transcription By RNA Polymerase II Insulin Secretion Pancreas Development Regulation Of Pronephros Size Renal D-glucose Absorption Glucose Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II D-glucose Import Positive Regulation Of Transcription Initiation By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Translational Elongation Translational Termination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Protein Ubiquitination Androgen Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Androgen Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Rescue Of Stalled Ribosome Protein K6-linked Ubiquitination Protein-RNA Covalent Cross-linking Repair
Pathways		Regulation of gene expression in beta cells	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		D-norleucine	None
Diseases		Maturity onset diabetes of the young (MODY)	None
GWAS		Acute insulin response ( 28490609 ) Age at first birth ( 34211149 ) Apolipoprotein B levels ( 32203549 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Birth weight ( 31043758 ) Blood protein levels in cardiovascular risk ( 28369058 ) Blood urea nitrogen levels ( 29403010 ) C-reactive protein ( 18439548 18439552 19567438 21196492 21647738 22939635 23844046 ) C-reactive protein and white blood cell count ( 22788528 ) C-reactive protein levels ( 21300955 24763700 29403010 29878111 30388399 31622379 33339817 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809 ) Ceramide levels (C22:0) ( 32489964 ) Chloride levels ( 29403010 ) Cholesterol, total ( 20686565 24097068 25961943 ) Chronic obstructive pulmonary disease-related biomarkers ( 23144326 ) Coronary artery disease ( 28714974 29212778 32469254 33020668 ) Coronary heart disease ( 19198612 ) Gallstone disease ( 30504769 ) Gamma glutamyl transferase levels ( 22010049 29403010 33339817 ) Gamma glutamyl transpeptidase ( 21909109 ) Glucosuria ( 30476138 ) Glucosuria (moderate to severe) ( 30476138 ) HDL cholesterol levels ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Hemoglobin levels ( 32327693 ) High-sensitivity C-reactive protein levels in HIV infection ( 33095540 ) Homocysteine levels ( 23824729 ) Insulinogenic index ( 23263489 ) LDL cholesterol ( 19060906 20686565 24097068 25961943 30275531 ) LDL cholesterol levels ( 28334899 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Liver enzyme levels ( 18940312 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 ) Longevity ( 20834067 ) Low density lipoprotein cholesterol levels ( 32154731 33339817 ) Myocardial infarction ( 33532862 ) N-glycan levels ( 21203500 21908519 ) Pancreatic cancer ( 26098869 29422604 ) Pancreatic ductal adenocarcinoma ( 30541042 ) Peak insulin response ( 28490609 ) Serum alkaline phosphatase levels ( 31666285 33339817 33547301 ) Serum alpha1-antitrypsin levels ( 26174136 ) Serum C-reactive protein concentration ( 32928877 ) Serum C-reactive protein concentration in high fat diet ( 32928877 ) Serum C-reactive protein concentration in low fat diet ( 32928877 ) Serum C-reactive protein concentration in non-obese individuals ( 32928877 ) Serum C-reactive protein concentration in obesity ( 32928877 ) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877 ) Serum C-reactive protein concentration in visceral obesity (waist-hip ratio) ( 32928877 ) Serum metabolite levels (CMS) ( 31636271 ) Stroke ( 32693751 ) Total cholesterol levels ( 28334899 30275531 ) Type 2 diabetes ( 20581827 21573907 22885922 24509480 26818947 28869590 29632382 30297969 30718926 32499647 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Urate levels ( 23263486 31578528 ) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659 )	Asthma ( 31959851 ) Superior temporal gyrus volume ( 31530798 )
Interacting Genes		24 interacting genes: ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B MYOG NCOA1 NCOA3 PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1 TLE5	23 interacting genes: AR DACH1 ESR1 HNF1A HNRNPA1 NCOA4 NR3C1 PHF7 TAGLN TENT5A TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2U UBE2V1 UBE2W VDR
Entrez ID		6927	9604
HPRD ID		00800	05745
Ensembl ID		ENSG00000135100	ENSG00000013561
Uniprot IDs		A0A0A0MTK8 E0YMI7 F5H0K0 P20823	B7Z229 Q9UBS8
PDB IDs		1IC8 2GYP 8PI7 8PI8 8PI9 8PIA	Not available
GO Terms Enriched among Interactors		Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Protein-lysine-acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Transcription Coactivator Activity DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Response To Nutrient Levels RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Cellular Response To Nutrient Levels Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Animal Organ Development Positive Regulation Of Cell Differentiation Cellular Response To Oxygen-containing Compound Sequence-specific DNA Binding Nucleus DNA-binding Transcription Factor Activity Chromatin Binding Developmental Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Monoubiquitination Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transferase Activity Nuclear Receptor-mediated Signaling Pathway Estrogen Response Element Binding Protein Modification Process Intracellular Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Receptor Activity Cellular Response To Estrogen Stimulus Hormone-mediated Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Nuclear Steroid Receptor Activity Estrogen Receptor Signaling Pathway Nucleus Negative Regulation Of Osteoclast Proliferation Nucleoplasm Steroid Binding ATP Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Mammary Gland Branching Involved In Pregnancy ISG15 Transferase Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Proteolysis Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Bone Mineralization ISG15-protein Conjugation Cellular Response To Lipid Cellular Response To Testosterone Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Biomineral Tissue Development Nucleotide Binding Macromolecule Catabolic Process Positive Regulation Of Ossification Protein-containing Complex