TBX6 and TOX4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TBX6	TOX4
Name		T-box transcription factor 6	TOX high mobility group box family member 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromosome, Telomeric Region Chromatin Nucleus Chromosome PTW/PP1 Phosphatase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Binding Chromatin DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mesoderm Development Mesodermal Cell Fate Specification Anatomical Structure Morphogenesis Negative Regulation Of Neuron Projection Development Negative Regulation Of Neuron Maturation Signal Transduction Involved In Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	RNA Polymerase II Promoter Clearance Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II
Pathways		Formation of paraxial mesoderm Somitogenesis Formation of the posterior neural plate	None
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Body fat distribution (arm fat ratio) ( 30664634 ) Brain morphology (MOSTest) ( 32665545 ) Eosinophil count ( 27863252 32888494 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) High light scatter reticulocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Menarche (age at onset) ( 25231870 ) Multiple sclerosis ( 31604244 ) Red blood cell count ( 29403010 27863252 32888494 ) Reticulocyte count ( 32888494 ) Schizophrenia ( 29483656 25056061 ) Sum eosinophil basophil counts ( 27863252 )	No GWAS studies recorded
Interacting Genes		39 interacting genes: ACTMAP C10orf55 C1orf94 CRX CYSRT1 DAZAP2 HSFY1 HSFY2 INTS11 KLHDC7B KRTAP11-1 KRTAP13-1 KRTAP6-2 KRTAP6-3 MAGED1 MEOX2 METTL27 MGAT5B PLA2G10 POU2AF1 POU6F2 PRMT1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RBPMS TBX15 TBX19 TCP11L1 TENT5B TLE5 TOX4 TSC1 USP54 YPEL3 ZNF34	16 interacting genes: ATXN1 BANP CCBE1 CREB1 EXOSC10 FNDC3B GEMIN6 HIPK3 HSPB1 MYL7 PPP1CA QRICH1 TBX6 WDR82 ZMYND19 ZNF512B
Entrez ID		6911	9878
HPRD ID		03888	12661
Ensembl ID		ENSG00000149922	ENSG00000092203
Uniprot IDs		O95947	O94842
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	RNA Polymerase II Promoter Clearance PTW/PP1 Phosphatase Complex RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription, Elongation DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Glial Cell Proliferation Chemotaxis To Arachidonate RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Protein Kinase C Signaling RNA Surveillance Nuclear RNA Surveillance Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Transforming Growth Factor Beta3 Production Visual Behavior Nucleic Acid Metabolic Process Visual Learning Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription Euchromatin RNA Binding Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Positive Regulation Of DNA-templated Transcription, Elongation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Transcription Elongation By RNA Polymerase II LncRNA Catabolic Process Negative Regulation Of LncRNA Transcription MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Transcription By RNA Polymerase II Response To Dehydroepiandrosterone Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process