TBX5 and KDM6A

Number of citations: 56 (PubMedID 22192413)
Data Source: BioGRID (two hybrid)

		TBX5	KDM6A
Name		T-box transcription factor 5	lysine demethylase 6A
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-containing Complex Protein-DNA Complex	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity
	Biological Process	Cell Fate Specification Morphogenesis Of An Epithelium Sinoatrial Node Development Bundle Of His Development Atrioventricular Bundle Cell Differentiation Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Atrial Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Proliferation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Gap Junction Assembly Positive Regulation Of Cardiac Conduction	Chromatin Organization Chromatin Remodeling Heart Development Regulation Of Gene Expression
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis	HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Diseases		Holt-Oram syndrome	None
GWAS		Airflow obstruction ( 22837378 ) Atrial fibrillation ( 30061737 33990960 29892015 28416822 28416818 ) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254 ) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027 ) Blood pressure ( 21909110 ) Bone mineral density (total hip) ( 29883787 ) Brugada syndrome ( 35210625 ) Diastolic blood pressure ( 19430479 28135244 27618452 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diverticular disease ( 30177863 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 20062063 ) Electrocardiographic traits (multivariate) ( 32602732 ) FEV1 ( 30804560 ) Hypertension ( 30487518 ) Laryngeal squamous cell carcinoma ( 25194280 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011 ) Mean arterial pressure ( 30487518 ) Obesity-related traits ( 23251661 ) P wave duration ( 28794112 ) Peak expiratory flow ( 30804560 ) Pelvic organ prolapse ( 32184442 ) Percent mammographic density ( 22532574 ) PR interval ( 32439900 20062060 30046033 25035420 23139255 21347284 ) Prostate cancer ( 25939597 23535732 ) QRS duration ( 30012220 27577874 21076409 ) Receptive language ability ( 32635940 ) Smoking status (ever vs never smokers) ( 30643258 ) Systolic blood pressure ( 27618452 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355 ) Visceral fat ( 22589738 )	No GWAS studies recorded
Interacting Genes		7 interacting genes: BAIAP2 FBXO25 GATA4 KAT5 KDM6A NKX2-5 ZMYND10	15 interacting genes: CREBBP GSC2 H3-4 H3C1 H3C14 HUNK MEOX2 MTDH NKX2-5 RSPH1 SMAD9 SRF TBX5 TLE1 TSPYL2
Entrez ID		6910	7403
HPRD ID		03372	02131
Ensembl ID		ENSG00000089225	ENSG00000147050
Uniprot IDs		Q99593	A0A087X0R0 A0A6Q8PFK0 A0A804HJA2 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3
PDB IDs		2X6U 2X6V 4S0H 5BQD	3AVR 3AVS 6FUK 6FUL
GO Terms Enriched among Interactors		Atrioventricular Node Development Atrial Septum Morphogenesis Aortic Valve Morphogenesis Cardiac Muscle Cell Differentiation Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cardiac Ventricle Morphogenesis DNA-binding Transcription Activator Activity Cardiac Muscle Tissue Development Heart Development Septum Secundum Development Cardiac Septum Development Nkx-2.5 Complex Cardiac Septum Morphogenesis Purkinje Myocyte Differentiation Mesenchyme Development Regulation Of Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Differentiation Cardiocyte Differentiation Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Muscle Cell Apoptotic Process Heart Valve Morphogenesis Cellular Response To Glucose Stimulus Cellular Response To Carbohydrate Stimulus Dendritic Spine Cytoplasm Neuron Projection Branch Point Histone H2AK5 Acetyltransferase Activity Positive Regulation Of Motile Cilium Assembly Regulation Of Stem Cell Differentiation Regulation Of Cardiac Muscle Contraction Intracellular Glucose Homeostasis Muscle Cell Differentiation Atrial Cardiac Muscle Cell Development Atrioventricular Node Cell Fate Commitment Regulation Of Striated Muscle Contraction Atrial Septum Secundum Morphogenesis Positive Regulation Of Organelle Organization Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Epithelial Tube Morphogenesis Striated Muscle Tissue Development His-Purkinje System Cell Differentiation Pulmonary Myocardium Development Proepicardium Development Positive Regulation Of Developmental Process Regulation Of System Process Ventricular Cardiac Myofibril Assembly Right Ventricular Cardiac Muscle Tissue Morphogenesis	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Atrioventricular Node Cell Fate Commitment Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus His-Purkinje System Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Transcription Regulator Complex Nucleosome Assembly DNA-binding Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Nucleosome Organization Cardiocyte Differentiation Muscle Tissue Development Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Atrial Septum Development Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Cardiac Chamber Formation Protein-DNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Atrial Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Regulation Of Primary Metabolic Process Muscle Cell Fate Commitment Heart Trabecula Formation Positive Regulation Of Cardiocyte Differentiation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cardiac Myofibril Assembly Structural Constituent Of Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Atrial Septum Morphogenesis Epithelium Development Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Regulation Of Metabolic Process Cellular Component Assembly Muscle Cell Differentiation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process