TAP2 and HLA-G

Number of citations: 0 (PubMedID 9103419)
Data Source: HPRD (in vivo)

		TAP2	HLA-G
Name		transporter 2, ATP binding cassette subfamily B member	major histocompatibility complex, class I, G
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Speck Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex TAP Complex	Golgi Membrane Extracellular Region Extracellular Space Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Filopodium Membrane Early Endosome Membrane Cis-Golgi Network Membrane MHC Class I Protein Complex Cell Projection Recycling Endosome Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATP Hydrolysis Activity MHC Class Ib Protein Binding MHC Protein Binding Peptide Antigen Binding Metal Ion Binding TAP1 Binding Tapasin Binding ABC-type Transporter Activity Peptide Transmembrane Transporter Activity	Signaling Receptor Binding Protein Binding Peptide Antigen Binding CD8 Receptor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Response To Molecule Of Bacterial Origin Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Peptide Antigen Transport Transmembrane Transport	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Peripheral B Cell Tolerance Induction Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response Cellular Defense Response Negative Regulation Of Angiogenesis Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Protection From Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Immune Response Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Negative Regulation Of G0 To G1 Transition Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of Dendritic Cell Differentiation
Pathways		ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type1	None
GWAS		Asthma ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Composite immunoglobulin trait (IgA/IgG) ( 28628107 ) Hemoglobin levels ( 32327693 ) Hip circumference adjusted for BMI ( 34021172 ) IgA nephropathy ( 25305756 ) Lymphocyte count ( 32888494 ) Lymphoma ( 23349640 ) Nephropathy ( 21399633 ) Platelet distribution width ( 32888494 ) Pubertal anthropometrics ( 23449627 ) Response to hepatitis B vaccine ( 29534301 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Type 1 diabetes (age at diagnosis) ( 33179336 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Urate levels in lean individuals ( 25811787 ) Waist circumference adjusted for body mass index ( 34021172 )	Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Childhood ear infection ( 27182965 ) Colorectal cancer ( 30529582 ) Crohn's disease ( 22412388 ) Eosinophil percentage of white cells ( 32888494 ) Glaucoma (primary open-angle) ( 33627673 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) IgE levels ( 22075330 ) IgM levels ( 28628107 ) LDL cholesterol levels ( 32203549 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 31577861 ) Neutrophil percentage of white cells ( 32888494 ) Non-albumin protein levels ( 29403010 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 ) Smoking status (ever vs never smokers) ( 30643258 ) Takayasu arteritis ( 25604533 33308445 ) Triglyceride levels ( 32203549 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		10 interacting genes: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP TMUB1	10 interacting genes: B2M CD8A CDC42 COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2
Entrez ID		6891	3135
HPRD ID		01360	00834
Ensembl ID		ENSG00000204267	ENSG00000204632
Uniprot IDs		Q03519 Q5JNW1 Q9UP03 X5CMH5	A0A0G2JNX1 P17693 Q31611 Q5RJ85 Q6DU14 Q8MH48
PDB IDs		5U1D 8T46 8T4E 8T4F 8T4G 8T4H 8T4I 8T4J	1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO 6AEE 6K60
GO Terms Enriched among Interactors		Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Peptide Antigen Phagocytic Vesicle Membrane Lumenal Side Of Endoplasmic Reticulum Membrane TAP2 Binding TAP1 Binding MHC Class I Peptide Loading Complex MHC Class I Protein Complex Threonine-type Endopeptidase Activity Peptide Antigen Assembly With MHC Class I Protein Complex Proteasome Core Complex, Beta-subunit Complex Protein-containing Complex Assembly Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Proteasome Assembly Protein Trimerization Protein-containing Complex Organization MHC Class I Protein Binding Proteasome Core Complex Early Endosome Membrane Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Immune System Process Regulation Of T Cell Mediated Cytotoxicity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway ER To Golgi Transport Vesicle Membrane Regulation Of Natural Killer Cell Mediated Immunity Adaptive Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Peripheral B Cell Tolerance Induction Proteasome Complex MHC Class Ib Protein Complex Assembly Peptide Antigen Stabilization Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity External Side Of Plasma Membrane Cellular Component Assembly Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Acetylcholine Receptor Activator Activity Lipoprotein Particle	MHC Class Ib Protein Binding Adaptive Immune Response MHC Class I Protein Binding Regulation Of Leukocyte Mediated Cytotoxicity MHC Class I Peptide Loading Complex Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Lymphocyte Mediated Immunity Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex MHC Class Ib Protein Complex Binding Positive Regulation Of Immune Effector Process Regulation Of Immune Response Regulation Of T Cell Mediated Immunity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Lymphocyte Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity ABC-type Peptide Transporter Activity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Mediated Immunity Peptide Antigen Binding Positive Regulation Of Immune Response Leukocyte Mediated Immunity Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib TAP1 Binding Immune System Process Immune Effector Process Immune Response-regulating Signaling Pathway Cytosol To Endoplasmic Reticulum Transport Fc Receptor Mediated Inhibitory Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity MHC Class Ib Receptor Activity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Adaptive Immune Response MHC Class I Protein Complex Binding MHC Protein Binding Inhibitory MHC Class I Receptor Activity Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Immune System Process Immune Response-inhibiting Cell Surface Receptor Signaling Pathway