AURKC and BIRC5

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		AURKC	BIRC5
Name		aurora kinase C	baculoviral IAP repeat containing 5
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Spindle Pole Nucleus Chromosome Cytoplasm Centrosome Spindle Cytoskeleton Spindle Microtubule Midbody Chromosome Passenger Complex Spindle Midzone	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centriole Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Midbody Interphase Microtubule Organizing Center Chromosome Passenger Complex Protein-containing Complex Spindle Midzone Survivin Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Enzyme Binding Peptidase Inhibitor Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Heterodimerization Activity Cobalt Ion Binding Protein-folding Chaperone Binding
	Biological Process	Protein Phosphorylation Mitotic Spindle Organization Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division Meiotic Cell Cycle	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Cytokinesis Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Protein-containing Complex Localization Positive Regulation Of Exit From Mitosis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Chromosome Localization Mitotic Spindle Midzone Assembly Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis
Pathways		None	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation
Drugs		SNS-314 Fostamatinib	Reserpine Berberine LY2181308
GWAS		No GWAS studies recorded	Blood trace element (Se levels) ( 23720494 ) Periodontitis (Mean PAL) ( 24024966 )
Interacting Genes		13 interacting genes: BIRC5 BIRC7 BRCA1 CADPS CENPA H3C1 INCENP LNX1 NEDD4 NEDD4L OTX2 SRPK1 TACC2	27 interacting genes: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 DIABLO EVI5 GAS2L3 H3-4 H3C14 HSP90AA1 INCENP KCNJ6 OGT RAN RASA1 STAMBPL1 XIAP XPO1
Entrez ID		6795	332
HPRD ID		04605	04520
Ensembl ID		ENSG00000105146	ENSG00000089685
Uniprot IDs		Q9UQB9	A0A0B4J1S3 H3BLT4 O15392
PDB IDs		6GR8 6GR9 9ESA	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH 7LBK 7LBO 7LBP 7LBQ 8RUP
GO Terms Enriched among Interactors		Ubiquitin-protein Transferase Activity Chromosome Segregation Microtubule Cytoskeleton Organization Involved In Mitosis Chromosome Ubiquitin Protein Ligase Activity Chromosome Passenger Complex Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein-containing Complex Organelle Localization Mitotic Cytokinesis Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Sodium Channel Inhibitor Activity Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Potassium Channel Inhibitor Activity Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Mitotic Spindle Organization Cytoskeleton-dependent Cytokinesis Regulation Of Mitotic Cytokinesis Lateral Element Negative Regulation Of Sodium Ion Transport Nucleoplasm Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint RNA Polymerase Binding Receptor Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Enzyme Binding Microtubule-based Process Spindle Organization Chromosome, Centromeric Region Positive Regulation Of Chromosome Segregation Pericentric Heterochromatin Negative Regulation Of Potassium Ion Transport Post-translational Protein Modification Cysteine-type Endopeptidase Inhibitor Activity Microtubule Cytoskeleton Organization Positive Regulation Of Chromosome Separation Neuromuscular Junction Development Positive Regulation Of Cytokinesis	Chromosome Passenger Complex Cell Division Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Midbody Mitotic Spindle Midzone Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Midzone Assembly Regulation Of Metaphase Plate Congression Spindle Microtubule Spindle Regulation Of Cytokinesis Spindle Organization Mitotic Spindle Organization Regulation Of Cell Cycle Apoptotic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Programmed Cell Death Cell Death Microtubule Cytoskeleton Organization Spindle Midzone Positive Regulation Of Chromosome Segregation Cytoplasm Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Programmed Cell Death Positive Regulation Of Cell Cycle Process Cytosol Fibroblast Apoptotic Process Spindle Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Division Protein Modification Process Chromocenter Positive Regulation Of Cytokinesis Protein-containing Complex Regulation Of Apoptotic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Neuron Apoptotic Process Transferase Activity Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cell Cycle Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint Cellular Response To Oxygen-containing Compound Mitotic Cell Cycle Mitotic Cytokinesis Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint