HSPA13 and BAG6

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		HSPA13	BAG6
Name		heat shock protein family A (Hsp70) member 13	BAG cochaperone 6
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome BAT3 Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone	Signaling Receptor Binding Protein Binding Hsp70 Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ribosome Binding Receptor Ligand Activity Misfolded Protein Binding Molecular Adaptor Activity Proteasome Binding Protein Carrier Chaperone Ubiquitin-specific Protease Binding
	Biological Process	Protein Folding Protein Refolding	Kidney Development Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Apoptotic Process Synaptonemal Complex Assembly Spermatogenesis Brain Development Proteasomal Protein Catabolic Process Internal Peptidyl-lysine Acetylation Natural Killer Cell Activation Cell Differentiation Lung Development Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ERAD Pathway Maintenance Of Unfolded Protein Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Embryonic Development Protein Stabilization NK T Cell Activation Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway
Pathways		Regulation of HSF1-mediated heat shock response	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Copper	None
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Malaria ( 31844061 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Schizophrenia ( 23894747 ) Small cell lung carcinoma ( 28604730 ) Smoking status (ever vs never smokers) ( 30643258 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT	120 interacting genes: ACVR1B AKT1 AMFR AMTN ANTKMT ANXA7 APBB1IP ARPC3 ATN1 ATXN2 B2M BCL2 C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CDSN CEBPA CHN2 CILK1 CLU CRIPTO CSNK2B CSTF2 CTAG1A CTAG1B CTCFL CTSB CTSE CTSL CXCL8 CYSRT1 DMKN DNAJB11 DPT DRC9 EDN1 EFEMP1 EFEMP2 ELP1 EP300 FAM9B FAS FKBP2 FZD4 GADD45A GLRA2 GOLGA6L9 GSK3B HSPA13 HSPA8 IGF2 IGFBP5 IMMT KLHL12 KPNA2 LBP MAP1LC3B MAPK6 MECOM MEST MTNR1A MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 PLPP2 PLPPR3 POLR2J PRKAR1B PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SERPINI2 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TENT5A TFCP2 TK1 TOMM20 TP53 TP63 TTR UBL7 UBQLN1 UBQLN2 UBQLN4 VAMP2 XRN1 ZFYVE9
Entrez ID		6782	7917
HPRD ID		03061	00808
Ensembl ID		ENSG00000155304	ENSG00000204463
Uniprot IDs		A0A140VK72 P48723	A0A1U9X7A6 A0A7P0MQS5 P46379
PDB IDs		Not available	1WX9 2N9P 4DWF 4EEW 4WWR 4X86 6AU8 7RU9 7RUA 7RUC
GO Terms Enriched among Interactors		Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process	Regulation Of Cellular Response To Stress Extracellular Space Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Extracellular Region Protein Binding Membrane Organization Receptor Ligand Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Endoplasmic Reticulum Stress Signal Transduction Response To Hormone Negative Regulation Of Proteolysis Extracellular Matrix Negative Regulation Of Cellular Component Organization Response To Lipid Tissue Development Regulation Of Protein Catabolic Process Tau Protein Binding Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Leukocyte Apoptotic Process Positive Regulation Of Neutrophil Chemotaxis Regulation Of Ossification G1/S Transition Of Mitotic Cell Cycle Protein-containing Complex Establishment Of Protein Localization To Organelle Molecular Function Activator Activity Cell Cycle G1/S Phase Transition Negative Regulation Of Developmental Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Multicellular Organismal Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Migration Regulation Of Developmental Process Response To Nutrient Levels Cellular Response To Oxygen-containing Compound Endoplasmic Reticulum Lumen T Cell Apoptotic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Signal Transduction