SPTAN1 and SPTB

Number of citations: 0 (PubMedID 9890967)
Data Source: HPRD (in vivo)

		SPTAN1	SPTB
Name		spectrin alpha, non-erythrocytic 1	spectrin beta, erythrocytic
Structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Cytoplasmic Side Of Plasma Membrane Cell Surface Spectrin-associated Cytoskeleton Actin Cytoskeleton Cell Junction Cortical Actin Cytoskeleton Protein-containing Complex Cell Projection Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process	Actin Cytoskeleton Organization Actin Filament Capping	Actin Cytoskeleton Organization Synapse Organization Actin Filament Capping Modification Of Postsynaptic Actin Cytoskeleton
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome	Hereditary spherocytosis (SPH) Hereditary elliptocytosis (HE)
GWAS		Axial length ( 24144296 ) Body mass index ( 26426971 )	Daytime sleep phenotypes ( 27126917 ) Glycated hemoglobin levels ( 34059833 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Obesity-related traits ( 23251661 ) Pediatric areal bone mineral density (radius) ( 28181694 ) Red cell distribution width ( 28957414 27863252 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Type 2 diabetes ( 31049640 )
Interacting Genes		60 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 TTC3 ZNF333	18 interacting genes: ACTB ADD1 ANK1 AP1G1 CSRP3 DMTN ENO3 EPB41 MAPT NCAM1 NRIP1 SH2D2A SNAPIN SPTA1 SPTAN1 STAT1 TULP3 YWHAQ
Entrez ID		6709	6710
HPRD ID		01684	01686
Ensembl ID		ENSG00000197694	ENSG00000070182
Uniprot IDs		A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813	P11277
PDB IDs		2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH	1S35 3EDU 3F57 3KBT 3KBU 3LBX
GO Terms Enriched among Interactors		Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite	Spectrin-associated Cytoskeleton Cortical Cytoskeleton Spectrin Binding Actin Filament Capping Structural Constituent Of Cytoskeleton Actin Cytoskeleton Organization Actin Binding Negative Regulation Of Actin Filament Depolymerization Actin Filament-based Process Cytosol Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Cytoskeleton Organization Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Regulation Of Cellular Component Size Cytoskeleton Regulation Of Actin Filament Polymerization Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Protein-containing Complex Assembly Organelle Organization Cytoplasm Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Spectrin Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Filament Binding Cell Junction Negative Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Assembly Axolemma Supramolecular Fiber Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Mesenchymal Cell Differentiation Regulation Of Cytoskeleton Organization Cytoskeletal Anchor Activity Protein Phosphatase 2A Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Protein Localization To Cell Periphery Kinesin Binding Axon Substantia Nigra Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Melanosome Organization Pigment Granule Organization