SPINK1 and CTRC

Number of citations: 0 (PubMedID 2093478)
Data Source: HPRD (in vitro)

		SPINK1	CTRC
Name		serine peptidase inhibitor Kazal type 1	chymotrypsin C
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	None
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Nitric Oxide Mediated Signal Transduction Negative Regulation Of Nitric Oxide Mediated Signal Transduction Sperm Capacitation Regulation Of Acrosome Reaction Negative Regulation Of Calcium Ion Import Regulation Of Store-operated Calcium Entry	Proteolysis Intracellular Calcium Ion Homeostasis
Pathways		Developmental Lineage of Pancreatic Acinar Cells	Developmental Lineage of Pancreatic Acinar Cells
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis Tropical calcific pancreatitis	Hereditary pancreatitis; Hereditary chronic pancreatitis Tropical calcific pancreatitis
GWAS		Alcoholic chronic pancreatitis ( 28754779 ) Blood protein levels ( 30072576 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483 )	Alcoholic chronic pancreatitis ( 28754779 )
Interacting Genes		6 interacting genes: ASPH CTRC ELN NRSN1 TMPRSS15 UBE3A	20 interacting genes: CYSRT1 GIPC2 KRT34 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP3-1 KRTAP6-2 KRTAP9-2 MDFI NEDD8 NFKBID PHKG1 SERPINA3 SPINK1 SPMIP9 ST13 UBC VGLL3
Entrez ID		6690	11330
HPRD ID		01341	03242
Ensembl ID		ENSG00000164266	ENSG00000162438
Uniprot IDs		P00995	Q99895
PDB IDs		1CGI 1CGJ 1HPT 7QE8 7QE9	4H4F
GO Terms Enriched among Interactors		Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Intracellular Chemical Homeostasis Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Intracellular Monoatomic Cation Homeostasis Serine-type Peptidase Activity Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Activity Sperm Entry Regulation Of Golgi Lumen Acidification Positive Regulation Of Golgi Lumen Acidification Cellular Homeostasis Activation Of Store-operated Calcium Channel Activity Elastic Fiber Serine-type Endopeptidase Activity Positive Regulation Of G0 To G1 Transition Purine Nucleotide Binding Positive Regulation Of Cellular PH Reduction Positive Regulation Of Store-operated Calcium Channel Activity Intracellular Calcium Ion Homeostasis Positive Regulation Of Protein Localization To Lysosome	Intermediate Filament Keratin Filament Protein Tag Activity