BPGM and CEL

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		BPGM	CEL
Name		bisphosphoglycerate mutase	carboxyl ester lipase
Structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Membrane Extracellular Exosome
	Molecular Function	Catalytic Activity Bisphosphoglycerate Mutase Activity Phosphoglycerate Mutase Activity Protein Binding Hydrolase Activity Isomerase Activity Intramolecular Phosphotransferase Activity	Catalytic Activity Sterol Ester Esterase Activity Triacylglycerol Lipase Activity Protein Binding Acetylesterase Activity Heparin Binding Hydrolase Activity Retinyl-palmitate Esterase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Carbohydrate Metabolic Process Glycolytic Process Nucleoside Phosphate Metabolic Process Respiratory Gaseous Exchange By Respiratory System Oxygen Transport Cellular Response To Stress Defense Response To Protozoan Erythrocyte Development Establishment Of Blood-brain Barrier Neuroinflammatory Response Carbohydrate Derivative Catabolic Process	Lipid Metabolic Process Lipid Catabolic Process Pancreatic Juice Secretion Intestinal Cholesterol Absorption Retinol Metabolic Process Ceramide Catabolic Process
Pathways		Glycolysis	Digestion of dietary lipid Developmental Lineage of Pancreatic Acinar Cells
Drugs		None	Taurocholic acid
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency	Maturity onset diabetes of the young (MODY)
GWAS		Blood protein levels ( 30072576 )	Blood protein levels ( 30072576 ) Early-onset Parkinson's disease ( 28256260 ) Type 1 diabetes ( 34012112 )
Interacting Genes		9 interacting genes: AKT1 ATF6 ATP4B CEL EGR2 EHD2 GAPDH GRB2 NEK3	3 interacting genes: BPGM LTF OLR1
Entrez ID		669	1056
HPRD ID		01961	07509
Ensembl ID		ENSG00000172331	ENSG00000170835
Uniprot IDs		A0A024R782 P07738	B4DSX9 O75612 P19835 Q86SR3
PDB IDs		1T8P 2A9J 2F90 2H4X 2H4Z 2H52 2HHJ 3NFY 7N3R 7N3S 7THI 8X2S	1F6W 1JMY 6H0T 6H0V 6H18 6H19 6H1A
GO Terms Enriched among Interactors		Insulin-like Growth Factor Receptor Signaling Pathway ER-nucleus Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Endoplasmic Reticulum Unfolded Protein Response Regulation Of Myelination Regulation Of TRNA Methylation Rhombomere 5 Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Endoplasmic Reticulum ERBB Signaling Pathway Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Regulation Of Response To Endoplasmic Reticulum Stress TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Regulation Of Autophagy Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Insulin Receptor Signaling Pathway Identical Protein Binding P-type Potassium:proton Transporter Activity Potassium:proton Exchanging ATPase Complex Acetylesterase Activity Rhombomere 3 Development Positive Regulation Of Schwann Cell Differentiation Brain Segmentation Myelination Axon Ensheathment Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Peptidyl-cysteine S-nitrosylase Activity Grb2-EGFR Complex Plasma Membrane Organization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Glucose Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Sterol Ester Esterase Activity Regulation Of Schwann Cell Differentiation Peptidyl-cysteine S-nitrosylation GAIT Complex	Phosphoglycerate Mutase Activity Defense Response Bisphosphoglycerate Mutase Activity Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Phagocytic Vesicle Lumen Membrane Destabilizing Activity Negative Regulation Of Osteoclast Development Intramolecular Phosphotransferase Activity Positive Regulation Of Chondrocyte Proliferation Regulation Of Osteoclast Development Establishment Of Blood-brain Barrier Negative Regulation Of ATP-dependent Activity Cytolysis By Host Of Symbiont Cells Negative Regulation Of Membrane Potential Specific Granule Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Antifungal Humoral Response Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Osteoblast Proliferation Neuroinflammatory Response Inflammatory Response Oxygen Transport Host-mediated Suppression Of Viral Proces Low-density Lipoprotein Particle Receptor Activity Innate Immune Response In Mucosa Respiratory Gaseous Exchange By Respiratory System Defense Response To Other Organism Response To Stress Response To Protozoan Erythrocyte Development Defense Response To Protozoan Cysteine-type Endopeptidase Inhibitor Activity Bone Morphogenesis Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Osteoblast Proliferation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of ATP-dependent Activity Mucosal Immune Response Negative Regulation Of Osteoclast Differentiation Killing By Host Of Symbiont Cells Organ Or Tissue Specific Immune Response Lipoprotein Metabolic Process Lipopolysaccharide Binding Biological Process Involved In Interaction With Symbiont ADP Catabolic Process ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process