SOD2 and NOL12

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		SOD2	NOL12
Name		superoxide dismutase 2	nucleolar protein 12
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Exosome	Nucleus Nucleolus Cytoplasm
	Molecular Function	DNA Binding Superoxide Dismutase Activity Protein Binding Oxidoreductase Activity Oxygen Binding Enzyme Binding Manganese Ion Binding Identical Protein Binding Metal Ion Binding	Single-stranded DNA Binding RNA Binding Protein Binding RRNA Binding Identical Protein Binding
	Biological Process	Response To Reactive Oxygen Species Response To Superoxide Response To Hypoxia Release Of Cytochrome C From Mitochondria Liver Development Detection Of Oxygen Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Glutathione Metabolic Process Superoxide Metabolic Process Response To Oxidative Stress Mitochondrion Organization Heart Development Locomotory Behavior Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Apoptotic Mitochondrial Changes Response To Xenobiotic Stimulus Post-embryonic Development Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Response To Gamma Radiation Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Activity Removal Of Superoxide Radicals Respiratory Electron Transport Chain Hemopoiesis Positive Regulation Of Cell Migration Response To Nutrient Levels Intracellular Oxygen Homeostasis Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Silicon Dioxide Cellular Response To Oxidative Stress Response To Isolation Stress Response To Immobilization Stress Vasodilation Response To Hydrogen Peroxide Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Response To Cadmium Ion Negative Regulation Of Fibroblast Proliferation Neuron Development Response To Axon Injury Erythrophore Differentiation Hydrogen Peroxide Biosynthetic Process Protein Homotetramerization Response To Electrical Stimulus Regulation Of Mitochondrial Membrane Potential Response To Hyperoxia Multicellular Organismal-level Iron Ion Homeostasis Response To Magnetism Cellular Response To Ethanol Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Membrane Hyperpolarization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	None
Pathways		Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Mitochondrial unfolded protein response (UPRmt)	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Benzylsulfonic acid 3-Fluoro-L-tyrosine Benzoyl peroxide	None
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) Lipoprotein (a) levels ( 26377243 ) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681 ) Polycystic ovary syndrome ( 32289280 ) Pulse pressure ( 27841878 )	Basophil count ( 32888494 ) Brain morphology (MOSTest) ( 32665545 ) Pulse pressure ( 30224653 )
Interacting Genes		9 interacting genes: APP CEP70 CYP4F12 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A	19 interacting genes: APP BEND7 CDCA7L CDK4 CEP70 DVL2 DVL3 KIAA1191 KRTAP10-6 KRTAP10-7 MCC SAP18 SF3B3 SLC25A38 SOD2 SPANXN2 SSX2IP TERF1 TSPYL2
Entrez ID		6648	79159
HPRD ID		00938	17537
Ensembl ID		ENSG00000291237	ENSG00000273899
Uniprot IDs		A0A384NL29 G5E9P6 P04179 Q96AM7	Q9UGY1
PDB IDs		1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T 5GXO 5T30 5VF9 7KKS 7KKU 7KKW 7KLB 8SKS 8VHW 8VHY 8VJ0 8VJ4 8VJ5 8VJ8 9BVY 9BW2 9BWM 9BWQ 9BWR	Not available
GO Terms Enriched among Interactors		None	Frizzled Binding Positive Regulation Of Neuron Projection Arborization Response To Manganese Ion Regulation Of Neuron Projection Arborization Positive Regulation Of JNK Cascade Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Nitric Oxide Metabolic Process Response To Xenobiotic Stimulus Wnt Signaling Pathway, Planar Cell Polarity Pathway Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation Negative Regulation Of DNA Replication Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Glycine Import Into Mitochondrion