SNCG and BUB1B

Number of citations: 0 (PubMedID 14576821)
Data Source: HPRD (in vitro, in vivo, two hybrid)

		SNCG	BUB1B
Name		synuclein gamma	BUB1 mitotic checkpoint serine/threonine kinase B
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Axon Neuronal Cell Body Axon Terminus Perinuclear Region Of Cytoplasm Extracellular Exosome	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Checkpoint Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Cuprous Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Chemical Synaptic Transmission Adult Locomotory Behavior Protein Secretion Regulation Of Dopamine Secretion Regulation Of Neurotransmitter Secretion Synaptic Vesicle Endocytosis Synapse Organization	Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Sister Chromatid Segregation Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region
Pathways		None	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		No GWAS studies recorded	Chronic lymphocytic leukemia ( 24292274 28165464 )
Interacting Genes		12 interacting genes: ADRB2 BUB1B GRK1 GRK5 GRK6 MAPK1 MAPK3 MAPK8 PCBP1 POT1 TERF1 TERF2IP	31 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DHX8 DNMBP FBXO7 HDAC1 HOPX KNL1 MAP3K4 PELI1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RIPK3 SNCG TP73 TRIP13
Entrez ID		6623	701
HPRD ID		04297	04176
Ensembl ID		ENSG00000173267	ENSG00000156970
Uniprot IDs		F8W754 O76070 Q6FHG5	O60566
PDB IDs		Not available	2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ
GO Terms Enriched among Interactors		Positive Regulation Of Telomere Maintenance Protein Serine/threonine Kinase Activity Regulation Of Chromosome Organization Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Shelterin Complex G Protein-coupled Receptor Kinase Activity Protein Kinase Activity Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Kinase Activity Telomere Capping MAP Kinase Activity Negative Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase Stress-activated MAPK Cascade Positive Regulation Of Organelle Organization Stress-activated Protein Kinase Signaling Cascade RNA-templated DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Interleukin-34-mediated Signaling Pathway Protein Phosphorylation Negative Regulation Of Telomere Maintenance Beta-adrenergic Receptor Kinase Activity Regulation Of Golgi Inheritance Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Phosphorylation Regulation Of Organelle Organization Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Phosphatase Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Cellular Response To Amino Acid Starvation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Amino Acid Starvation Nucleobase-containing Compound Biosynthetic Process ATP Binding Regulation Of DNA Metabolic Process Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Telomeric D-loop Disassembly Bergmann Glial Cell Differentiation Telomeric Loop Disassembly DNA Biosynthetic Process Telomere Maintenance	Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Protein Phosphatase Type 2A Complex Protein Phosphatase Activator Activity Cytosol Regulation Of Mitotic Nuclear Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Clathrin Adaptor Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Phosphatase Regulator Activity Regulation Of Cell Cycle Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Membrane Coat Mitotic Spindle Assembly Checkpoint Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Nuclear Division Regulation Of Reproductive Process Cell Division Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Chromosome Organization Chromosome Spindle Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Process Protein Catabolic Process Kinetochore Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Organization Centrosome Mitotic Checkpoint Complex Proteolysis Involved In Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator