SLN and ATP2A1

Number of citations: 30 (PubMedID 12692302)
Data Source: HPRD (in vivo)

		SLN	ATP2A1
Name		sarcolipin	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane H Zone I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Regulator Activity ATPase Binding	Nucleotide Binding P-type Calcium Transporter Activity Calcium Ion Binding Protein Binding ATP Binding ATP Hydrolysis Activity Calcium-dependent ATPase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Calcium Ion Transport Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Calcium Ion Transport Negative Regulation Of Calcium Ion Import Positive Regulation Of Cold-induced Thermogenesis Regulation Of Relaxation Of Muscle Positive Regulation Of Protein Depolymerization Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Striated Muscle Contraction Apoptotic Mitochondrial Changes Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Mitochondrial Calcium Ion Concentration Maintenance Of Mitochondrion Location Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Import Calcium Ion Transmembrane Transport Relaxation Of Skeletal Muscle Positive Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways		Ion homeostasis Ion transport by P-type ATPases	Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs		None	Enflurane Ritodrine Desflurane Sevoflurane Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Tetrafluoroaluminate Ion 2,5-di-tert-butylhydroquinone (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE
Diseases		None	Brody myopathy
GWAS		No GWAS studies recorded	BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body mass index ( 25673413 26961502 28892062 19079260 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Brain morphology (MOSTest) ( 32665545 ) Cannabis use ( 30150663 ) Crohn's disease ( 28067908 ) Extremely high intelligence ( 29520040 ) Hip circumference ( 31453325 25673412 ) Hip circumference variance ( 31453325 ) Inflammatory bowel disease ( 28067908 ) Intelligence ( 28530673 ) Intelligence (MTAG) ( 29326435 ) Lamb consumption ( 32066663 ) Type 2 diabetes ( 30297969 ) Waist circumference ( 31453325 ) Waist circumference variance ( 31453325 ) Weight ( 19079260 )
Interacting Genes		7 interacting genes: ATP2A1 KASH5 LMNA PLN PTPN11 SYNE4 TMEM79	8 interacting genes: APPL1 CCR8 IRS1 IRS2 PLN RNF167 SLN TULP3
Entrez ID		6588	487
HPRD ID		03729	00157
Ensembl ID		ENSG00000170290	ENSG00000196296
Uniprot IDs		A0A158RFT9 O00631	O14983
PDB IDs		1JDM	Not available
GO Terms Enriched among Interactors		Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Meiotic Nuclear Membrane Microtubule Tethering Complex Relaxation Of Muscle Regulation Of Cardiac Muscle Cell Contraction Regulation Of ATP-dependent Activity Regulation Of System Process Nuclear Envelope Nuclear Outer Membrane Sarcoplasmic Reticulum Membrane Regulation Of Muscle System Process Regulation Of Intracellular Transport Maintenance Of Mitochondrion Location Calcium-dependent ATPase Activity Sarcoplasmic Reticulum Regulation Of Transmembrane Transporter Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Relaxation Of Skeletal Muscle H Zone Regulation Of Cardiac Muscle Contraction Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction Regulation Of Striated Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transporter Activity DNA Double-strand Break Attachment To Nuclear Envelope Chromosome Localization Structural Constituent Of Nuclear Lamina Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Intestinal Epithelial Cell Migration Meiotic Spindle Pole Organelle Localization Developmental Process Negative Regulation Of Multicellular Organismal Process Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Cellular Localization Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Cerebellar Cortex Formation Cuticle Development Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Circadian Sleep/wake Cycle Process Negative Regulation Of Glucocorticoid Secretion Anterior Head Development	Negative Regulation Of Transport Positive Regulation Of D-glucose Import Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of D-glucose Transmembrane Transport Regulation Of D-glucose Import Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of D-glucose Transmembrane Transport Insulin Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of ATP-dependent Activity Positive Regulation Of Fatty Acid Oxidation Negative Regulation Of Calcium Ion Import Negative Regulation Of Transmembrane Transport Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Relaxation Of Muscle Insulin Receptor Binding Response To Insulin Cell Surface Receptor Signaling Pathway Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Transporter Activity Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of ATP-dependent Activity Positive Regulation Of Fatty Acid Metabolic Process Sarcoplasmic Reticulum Membrane Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Glycogen Metabolic Process Regulation Of Calcium Ion Import Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Calcium Ion Transport Regulation Of Transport Response To Peptide Hormone Negative Regulation Of Intracellular Transport Regulation Of Lipid Catabolic Process Enzyme Inhibitor Activity Sarcoplasmic Reticulum Negative Regulation Of Cation Transmembrane Transport Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Monoatomic Ion Transmembrane Transport Signaling Adaptor Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity