SLCO1A2 and NHERF2

Number of citations: 0 (PubMedID 15553237)
Data Source: HPRD (two hybrid)

		SLCO1A2	NHERF2
Name		solute carrier organic anion transporter family member 1A2	NHERF family PDZ scaffold protein 2
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Xenobiotic Metabolic Process Monoatomic Ion Transport Lipid Transport Organic Cation Transport Organic Anion Transport Bile Acid And Bile Salt Transport Sodium-independent Organic Anion Transport Transmembrane Transport	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		Recycling of bile acids and salts Organic anion transport by SLCO transporters Ciprofloxacin ADME	None
GWAS		AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875 ) Bilirubin levels ( 19414484 ) Diisocyanate-induced asthma ( 25918132 ) Methotrexate pharmacokinetics (acute lymphoblastic leukemia) ( 19901119 ) Post bronchodilator percent predicted FEV1 in smoking ( 30068317 ) Progressive supranuclear palsy ( 21685912 30089514 ) Rocuronium dose requirement in breast cancer surgery ( 33676726 ) Serum metabolite levels ( 23093944 ) Statin-induced myopathy (severe) ( 31220337 )	No GWAS studies recorded
Interacting Genes		4 interacting genes: NHERF1 NHERF2 NHERF4 PDZK1	46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1
Entrez ID		6579	9351
HPRD ID		09112	05946
Ensembl ID		ENSG00000084453	ENSG00000065054
Uniprot IDs		B4DJE6 P46721	H3BQS0 Q15599
PDB IDs		Not available	2D11 2HE4 2OCS 4P0C
GO Terms Enriched among Interactors		Protein-membrane Adaptor Activity Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Membrane Type 3 Metabotropic Glutamate Receptor Binding Apical Plasma Membrane Signaling Receptor Binding Localization Within Membrane Microvillus Membrane Cellular Localization Brush Border Membrane Phosphatase Binding Brush Border Intracellular Protein Localization PDZ Domain Binding Apical Part Of Cell Beta-catenin Binding Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Molecular Adaptor Activity Scavenger Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Endomembrane System Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Glutathione Transport Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Monoatomic Anion Transport Xenobiotic Export From Cell Quaternary Ammonium Group Transport	Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis