SLCO1A2 and PDZK1

Number of citations: 0 (PubMedID 15553237)
Data Source: HPRD (two hybrid)

		SLCO1A2	PDZK1
Name		solute carrier organic anion transporter family member 1A2	PDZ domain containing 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane	Plasma Membrane Brush Border Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Extracellular Exosome
	Molecular Function	Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity	Signaling Receptor Binding Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding Transporter Activator Activity
	Biological Process	Xenobiotic Metabolic Process Monoatomic Ion Transport Lipid Transport Organic Cation Transport Organic Anion Transport Bile Acid And Bile Salt Transport Sodium-independent Organic Anion Transport Transmembrane Transport	Regulation Of Monoatomic Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Carnitine Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Recycling of bile acids and salts Organic anion transport by SLCO transporters Ciprofloxacin ADME	None
GWAS		AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875 ) Bilirubin levels ( 19414484 ) Diisocyanate-induced asthma ( 25918132 ) Methotrexate pharmacokinetics (acute lymphoblastic leukemia) ( 19901119 ) Post bronchodilator percent predicted FEV1 in smoking ( 30068317 ) Progressive supranuclear palsy ( 21685912 30089514 ) Rocuronium dose requirement in breast cancer surgery ( 33676726 ) Serum metabolite levels ( 23093944 ) Statin-induced myopathy (severe) ( 31220337 )	Contrast sensitivity ( 24152035 ) Gout ( 32238385 33832965 ) Serum uric acid levels ( 30993211 ) Urate levels ( 20884846 23263486 31578528 31985003 ) Urate levels in overweight individuals ( 25811787 ) Uric acid levels ( 19503597 )
Interacting Genes		4 interacting genes: NHERF1 NHERF2 NHERF4 PDZK1	30 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP NHERF2 PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLCO1A2 SLK SSTR5 UBE2I
Entrez ID		6579	5174
HPRD ID		09112	04829
Ensembl ID		ENSG00000084453	ENSG00000174827
Uniprot IDs		B4DJE6 P46721	B2R7S7 Q5T2W1
PDB IDs		Not available	2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
GO Terms Enriched among Interactors		Protein-membrane Adaptor Activity Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Membrane Type 3 Metabotropic Glutamate Receptor Binding Apical Plasma Membrane Signaling Receptor Binding Localization Within Membrane Microvillus Membrane Cellular Localization Brush Border Membrane Phosphatase Binding Brush Border Intracellular Protein Localization PDZ Domain Binding Apical Part Of Cell Beta-catenin Binding Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Molecular Adaptor Activity Scavenger Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Endomembrane System Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Glutathione Transport Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Monoatomic Anion Transport Xenobiotic Export From Cell Quaternary Ammonium Group Transport	Apical Plasma Membrane Transmembrane Transport PDZ Domain Binding Monoatomic Ion Transport Organic Anion Transport Transmembrane Transporter Activity Brush Border Membrane Plasma Membrane Inorganic Anion Transport Organic Hydroxy Compound Transport Carboxylic Acid Transport Organic Acid Transport Xenobiotic Transport Symporter Activity Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Monoatomic Anion Transport Membrane Urate Transport Monoatomic Ion Transmembrane Transport Urate Metabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sodium Ion Transport ABC-type Transporter Activity Lipid Transport Cell Surface Xenobiotic Export From Cell Monocarboxylic Acid Transport Apolipoprotein Binding Export Across Plasma Membrane Organic Anion Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Basal Plasma Membrane Import Across Plasma Membrane Vascular Process In Circulatory System Bile Acid And Bile Salt Transport Xenobiotic Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Chemical Homeostasis Transport Across Blood-brain Barrier Regulation Of Intracellular PH Organic Cation Transport Regulation Of Cellular PH Circulatory System Process Inorganic Ion Transmembrane Transport Carnitine Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Antiporter Activity Peptide Transport Regulation Of PH