SLC9A5 and CHP2

Number of citations: 172 (PubMedID 40355756)
Data Source: BioGRID (pull down, affinity chromatography technology)

		SLC9A5	CHP2
Name		solute carrier family 9 member A5	calcineurin like EF-hand protein 2
Structure		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Focal Adhesion Membrane Dendritic Spine Membrane Cell Projection Neuron Spine Synapse Postsynaptic Membrane Recycling Endosome Membrane Anchoring Junction Synaptic Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Arrestin Family Protein Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport	Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatase Activity Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Calcium Ion
Pathways		Sodium/Proton exchangers	None
GWAS		A body shape index ( 34021172 ) High density lipoprotein cholesterol levels ( 33339817 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Daytime nap ( 33568662 )
Interacting Genes		5 interacting genes: ARRB1 ARRB2 CHP1 CHP2 RACK1	6 interacting genes: MDFI SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5
Entrez ID		6553	63928
HPRD ID		02723	14259
Ensembl ID		ENSG00000135740	ENSG00000166869
Uniprot IDs		Q14940	O43745
PDB IDs		Not available	2BEC
GO Terms Enriched among Interactors		Angiotensin Receptor Binding Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Transport Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Protein Ubiquitination Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Post-translational Protein Modification Negative Adaptation Of Signaling Pathway Regulation Of Phosphatase Activity G Protein-coupled Receptor Internalization Regulation Of Phosphorus Metabolic Process Regulation Of Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Regulation Of DNA-binding Transcription Factor Activity Molecular Adaptor Activity Regulation Of Protein Ubiquitination Regulation Of Dephosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Receptor Internalization Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Transport Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Endocytosis Positive Regulation Of Establishment Of Protein Localization Protein Transport Negative Regulation Of Interleukin-6 Production Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Modification Process Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Phosphorylation Enzyme Binding Regulation Of Protein Import Into Nucleus Establishment Of Protein Localization Regulation Of Phosphorylation Receptor Internalization Regulation Of Signal Transduction Clathrin-coated Pit Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Protein Localization Regulation Of Protein Transport Endocytic Vesicle Membrane G Protein-coupled Receptor Binding Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Receptor Internalization	Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Sodium Ion Import Across Plasma Membrane Regulation Of Cellular PH Regulation Of Intracellular PH Antiporter Activity Inorganic Cation Import Across Plasma Membrane Regulation Of PH Sodium Ion Transmembrane Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Proton Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Chemical Homeostasis Apical Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Homeostatic Process Recycling Endosome Membrane Regulation Of The Force Of Heart Contraction By Cardiac Conduction Cation-transporting ATPase Complex Regulation Of Biological Quality Transporter Complex Transepithelial Ammonium Transport Positive Regulation Of The Force Of Heart Contraction Glandular Epithelial Cell Development Regulation Of Cardiac Muscle Cell Membrane Potential Protein Phosphatase 2B Binding Neuron Spine Dynactin Complex Gastric Acid Secretion Cardiac Muscle Cell Contraction Positive Regulation Of Action Potential Arrestin Family Protein Binding Cellular Response To Antibiotic Basolateral Plasma Membrane