SLC9A3 and CHP1

Number of citations: 41 (PubMedID 8901634)
Data Source: HPRD (in vitro, in vivo)

		SLC9A3	CHP1
Name		solute carrier family 9 member A3	calcineurin like EF-hand protein 1
Structure
GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Brush Border Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytoskeleton Plasma Membrane Focal Adhesion Endomembrane System Microtubule Cytoskeleton Membrane Transport Vesicle Membrane Raft Extracellular Exosome Transporter Complex
	Molecular Function	Protein Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity PDZ Domain Binding Phosphatidylinositol Binding Identical Protein Binding	Protein Kinase Inhibitor Activity Calcium Ion Binding Protein Binding Microtubule Binding Sodium:proton Antiporter Activity Potassium Channel Regulator Activity Kinase Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport	Microtubule Bundle Formation Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Potassium Ion Transport Small GTPase-mediated Signal Transduction Negative Regulation Of Phosphatase Activity Protein Transport Membrane Docking Cytoplasmic Microtubule Organization Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sodium:proton Antiporter Activity Sodium Ion Transmembrane Transport Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Import Into Nucleus Protein Stabilization Positive Regulation Of Protein Transport Regulation Of Intracellular PH Positive Regulation Of Protein Glycosylation Membrane Organization Membrane Fusion Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Acidic PH Positive Regulation Of Protein Targeting To Membrane
Pathways		Sodium/Proton exchangers	Hyaluronan degradation
Drugs		Tenapanor	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877 ) Estimated glomerular filtration rate ( 31152163 ) Lung disease severity in cystic fibrosis ( 26417704 ) Ulcerative colitis ( 23128233 28067908 )	Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Essential hypertension (time to event) ( 32589924 ) Estimated glomerular filtration rate ( 31015462 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 32888494 )
Interacting Genes		9 interacting genes: CHP1 CHP2 LRP2 MAST2 NEDD4L NHERF1 NHERF2 PDZK1 SHANK2	10 interacting genes: GAPDH KIF1B PRSS23 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 STK17B UBC
Entrez ID		6550	11261
HPRD ID		01660	06101
Ensembl ID		ENSG00000066230	ENSG00000187446
Uniprot IDs		P48764	H0YKE7 Q99653
PDB IDs		7X2U	2E30 7DSV 7DSX 7X2U
GO Terms Enriched among Interactors		Brush Border Membrane Apical Plasma Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 3 Metabotropic Glutamate Receptor Binding Plasma Membrane Phosphatase Binding Regulation Of Sodium Ion Transport Regulation Of Phosphatase Activity Negative Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Import Across Plasma Membrane Regulation Of Dephosphorylation Positive Regulation Of Protein Targeting To Membrane Microvillus Membrane Sodium Ion Transport Protein Localization To Plasma Membrane Regulation Of Protein Targeting To Membrane Intracellular Protein Localization Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Sodium Ion Transmembrane Transport Transmembrane Transport Metal Ion Transport Protein Localization To Cell Periphery Extracellular Exosome Endomembrane System Brush Border Regulation Of Protein Import Into Nucleus Renal Phosphate Ion Absorption Monoatomic Cation Transport Protein Localization To Membrane Positive Regulation Of Establishment Of Protein Localization Regulation Of Metal Ion Transport Transport Across Blood-brain Barrier PDZ Domain Binding Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Apical Part Of Cell Regulation Of Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Monoatomic Ion Transport Regulation Of Protein Localization Signaling Receptor Binding Regulation Of Calcium-mediated Signaling Negative Regulation Of Monoatomic Ion Transport Beta-catenin Binding Membrane Folate Transmembrane Transport	Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Sodium Ion Import Across Plasma Membrane Regulation Of Cellular PH Regulation Of Intracellular PH Antiporter Activity Inorganic Cation Import Across Plasma Membrane Regulation Of PH Sodium Ion Transmembrane Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Proton Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Apical Plasma Membrane Chemical Homeostasis Monoatomic Ion Transport Transmembrane Transport Homeostatic Process Plasma Membrane Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Regulation Of The Force Of Heart Contraction By Cardiac Conduction Cation-transporting ATPase Complex Regulation Of Biological Quality Recycling Endosome Membrane Membrane Peptidyl-cysteine S-nitrosylase Activity Peptidyl-cysteine S-nitrosylation GAIT Complex Transporter Complex Transepithelial Ammonium Transport Positive Regulation Of The Force Of Heart Contraction Retrograde Neuronal Dense Core Vesicle Transport Glandular Epithelial Cell Development Extracellular Exosome Aspartic-type Endopeptidase Inhibitor Activity