SLC1A5 and ERVW-1

Number of citations: 63 (PubMedID 12050356)
Data Source: HPRD (in vitro, in vivo)

		SLC1A5	ERVW-1
Name		solute carrier family 1 member 5	endogenous retrovirus group W member 1, envelope
Structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Centriolar Satellite Ciliary Basal Body Melanosome Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity Symporter Activity Antiporter Activity Ligand-gated Channel Activity Signaling Receptor Activity Metal Ion Binding	None
	Biological Process	Amino Acid Transport Glutamine Transport Glutamine Secretion Neutral Amino Acid Transport L-serine Transport Erythrocyte Differentiation Symbiont Entry Into Host Cell Protein Homotrimerization L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier L-glutamine Import Across Plasma Membrane	Syncytium Formation By Plasma Membrane Fusion Syncytium Formation Myoblast Fusion Anatomical Structure Morphogenesis
Pathways		Amino acid transport across the plasma membrane RAC1 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle	None
Drugs		Asparagine Fluciclovine (18F)	None
GWAS		Appendicular lean mass ( 33097823 ) Conjunctival UV autofluorescence (CUVAF) ( 25590795 ) Metabolite levels ( 23823483 )	No GWAS studies recorded
Interacting Genes		6 interacting genes: APOL3 ERVW-1 PLP1 SLC25A21-AS1 TBC1D17 TRARG1	2 interacting genes: SLC1A4 SLC1A5
Entrez ID		6510	30816
HPRD ID		00173	05231
Ensembl ID		ENSG00000105281	ENSG00000242950
Uniprot IDs		Q15758 Q59ES3	D0EYG5 Q9UQF0
PDB IDs		5LLM 5LLU 5LM4 5MJU 6GCT 6MP6 6MPB 6RVX 6RVY 7BCQ 7BCS 7BCT 8OUD 8OUH 8OUJ 8QRO 8QRP 8QRQ 8QRR 8QRS 8QRU 8QRV 8QRW	5HA6 6RX1 8OUH 8OUJ
GO Terms Enriched among Interactors		None	L-serine Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity Glutamine Transport Serine Transport L-aspartate Transmembrane Transport L-aspartate Import Across Plasma Membrane L-serine Transport L-aspartate Transmembrane Transporter Activity Aspartate Transmembrane Transport Neutral L-amino Acid Transmembrane Transporter Activity C4-dicarboxylate Transport Amino Acid Transmembrane Transporter Activity Amino Acid Import Across Plasma Membrane Neutral Amino Acid Transport L-alpha-amino Acid Transmembrane Transport L-amino Acid Transport Dicarboxylic Acid Transport Transport Across Blood-brain Barrier Organic Cation Transport Amino Acid Transmembrane Transport Symporter Activity Melanosome Amino Acid Transport Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Import Across Plasma Membrane Hydroxyproline Transport L-hydroxyproline Transmembrane Transporter Activity L-threonine Transmembrane Transporter Activity Threonine Transport Carboxylic Acid Transport Organic Acid Transport Glutamine Secretion Vascular Process In Circulatory System Serine Import Across Plasma Membrane L-serine Import Across Plasma Membrane Circulatory System Process Organic Anion Transport L-proline Transmembrane Transporter Activity L-cystine Transmembrane Transporter Activity L-alanine Import Across Plasma Membrane Ligand-gated Channel Activity L-alanine Transmembrane Transport L-glutamine Import Across Plasma Membrane L-alanine Transmembrane Transporter Activity Proline Transmembrane Transport L-cystine Transport L-alanine Transport Proline Transport Import Into Cell