SLC4A3 and CA4

Number of citations: 0 (PubMedID 11994299)
Data Source: HPRD (in vitro, in vivo)

		SLC4A3	CA4
Name		solute carrier family 4 member 3	carbonic anhydrase 4
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Brush Border Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Side Of Membrane
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Lyase Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Anion Transport Inorganic Anion Transport Bicarbonate Transport PH Reduction Regulation Of Intracellular PH Transmembrane Transport Cardiac Conduction Cardiac Muscle Cell Action Potential Monoatomic Anion Transmembrane Transport Regulation Of Cardiac Muscle Cell Action Potential Transport Across Blood-brain Barrier Chloride Transmembrane Transport	Bicarbonate Transport
Pathways		Bicarbonate transporters	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide
Drugs		None	Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Zonisamide Trichlormethiazide Diclofenamide Brinzolamide Ellagic acid Sodium carbonate
Diseases		None	Retinitis pigmentosa (RP)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Height ( 33713608 ) Immune response to measles-mumps-rubella vaccine ( 24811271 ) QT interval ( 29874175 )	No GWAS studies recorded
Interacting Genes		6 interacting genes: ANK1 CA2 CA4 DRD2 PRKCE UBASH3A	5 interacting genes: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4
Entrez ID		6508	762
HPRD ID		00109	00261
Ensembl ID		ENSG00000114923	ENSG00000167434
Uniprot IDs		P48751	P22748
PDB IDs		8Y85 8Y86 8Y8K 8ZLE	1ZNC 3F7B 3F7U 3FW3 5IPZ 5JN8 5JN9 5JNA 5JNC 5KU6
GO Terms Enriched among Interactors		Regulation Of Synaptic Transmission, GABAergic Secretion Positive Regulation Of Synaptic Transmission Carbonate Dehydratase Activity Positive Regulation Of Synaptic Transmission, GABAergic Cellular Response To Ethanol Response To Morphine Positive Regulation Of Cytokinesis Cell Periphery Positive Regulation Of Dipeptide Transmembrane Transport Regulation Of Monoatomic Ion Transport Cyanamide Hydratase Activity Modulation Of Chemical Synaptic Transmission Response To Alkaloid Positive Regulation Of Cell Division Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Response To Ethanol G Protein-coupled Receptor Complex Regulation Of Sodium Ion Transport Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Cytokinesis Ethanol Binding Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Hormone Secretion Lyase Activity Regulation Of Insulin Secretion Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Toxin Catabolic Process Arylesterase Activity Positive Regulation Of Cellular PH Reduction Positive Regulation Of Transport Regulation Of Chloride Transport Regulation Of Peptide Hormone Secretion Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression	Monoatomic Anion Transmembrane Transporter Activity Solute:inorganic Anion Antiporter Activity Bicarbonate Transport Bicarbonate Transmembrane Transporter Activity Regulation Of Cellular PH Regulation Of Intracellular PH Regulation Of PH Chloride:bicarbonate Antiporter Activity Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Cellular Homeostasis Organic Anion Transport Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Transport Across Blood-brain Barrier Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process PH Elevation Respiratory Burst Involved In Inflammatory Response Homeostatic Process Monoatomic Ion Homeostasis Regulation Of Biological Quality Monoatomic Cation Homeostasis Antiporter Activity Chloride Transmembrane Transport Intracellular Chemical Homeostasis Chloride Transport Inorganic Anion Transmembrane Transport Cellular Response To Triglyceride RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding TORC1 Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Glucose Mediated Signaling Pathway Inorganic Ion Transmembrane Transport Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Response To Triglyceride Sodium:bicarbonate Symporter Activity Regulation Of Glucose Mediated Signaling Pathway Monoatomic Ion Transmembrane Transport Negative Regulation Of Urine Volume Hemoglobin Binding Thioredoxin-dependent Peroxiredoxin Activity Annulate Lamellae SnoRNA Localization R2TP Complex Peroxiredoxin Activity Thioredoxin Peroxidase Activity