CENPH and MTAP

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		CENPH	MTAP
Name		centromere protein H	methylthioadenosine phosphorylase
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Kinetochore Binding	Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity S-methyl-5-thioadenosine Phosphorylase Activity
	Biological Process	Mitotic Spindle Organization Chromosome Segregation Kinetochore Assembly Kinetochore Organization	Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Nicotinamide Riboside Catabolic Process Nucleoside Metabolic Process L-methionine Salvage From Methylthioadenosine Methylation Response To Testosterone
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		None	Adenine (2S,3S,4R,5S)-2-(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-3,4-pyrrolidinediol Formycin 5'-S-methyl-5'-thioadenosine 5'-Deoxy-5'-(Methylthio)-Tubercidin
GWAS		No GWAS studies recorded	Adverse response to drug ( 30420678 ) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Coronary heart disease ( 21606135 ) Cutaneous malignant melanoma ( 32341527 ) Cutaneous nevi ( 19578365 ) Diastolic blood pressure ( 28135244 ) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415 ) Glycated hemoglobin levels ( 28898252 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Lung cancer in never smokers ( 28604730 ) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011 ) Macular thickness ( 30535121 ) Mean spheric corpuscular volume ( 32888494 ) Melanoma ( 28212542 21983787 ) Nevus count ( 30429480 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Pediatric bone mineral content (radius) ( 26041818 ) Pulse pressure ( 28135244 )
Interacting Genes		19 interacting genes: ABI2 C1orf216 C8orf58 CCDC146 CRYAA DCTN2 ERH H2AP KIF2C LMNB1 MESD MTAP NUF2 NUP54 RASSF4 SPAG5 UBC ZNF493 ZSCAN12	7 interacting genes: CDC25A CENPH EMC3 FOLH1 LYRM1 MYLIP RELB
Entrez ID		64946	4507
HPRD ID		12029	01134
Ensembl ID		ENSG00000153044	ENSG00000099810
Uniprot IDs		A0A0S2Z5T0 Q9H3R5	A0A384ME80 B4DUC8 Q13126
PDB IDs		7PB4 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH	1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE 5EUB 5TC5 5TC6 5TC7 5TC8 6DYZ 6DZ0 6DZ2 6DZ3
GO Terms Enriched among Interactors		Lens Fiber Cell Morphogenesis Kinetochore Nuclear Chromosome Segregation Cytoskeleton Organization Protein Localization To Nuclear Envelope Microtubule Cytoskeleton Organization Nucleus Organization Microtubule-based Process Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Centrosome Microtubule Plus-end Chromosome Segregation Organelle Organization Spindle Organization Chromosome, Centromeric Region Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Cell Morphogenesis Nucleoside Metabolic Process Midbody S-methyl-5-thioadenosine Phosphorylase Activity Mitotic Metaphase Chromosome Alignment Protein Localization To Cytoskeleton Organelle Localization Structural Constituent Of Nuclear Lamina Nicotinamide Riboside Catabolic Process Zonula Adherens Assembly Metaphase Chromosome Alignment Regulation Of Cellular Localization Microtubule Binding Establishment Of Organelle Localization Protein Localization To Nuclear Inner Membrane	Intestinal Folate Absorption Tetrahydrofolyl-poly(glutamate) Polymer Binding Ac-Asp-Glu Binding Release Of Sequestered Calcium Ion Into Cytosol Metanephric Cortical Collecting Duct Development Cellular Response To Osmotic Stress Metanephric Cortex Development Metanephric Distal Tubule Development Negative Regulation Of Sequestering Of Calcium Ion G-protein Beta/gamma-subunit Complex Cytoskeletal Protein Binding Response To Osmotic Stress Calcium Ion Transmembrane Import Into Cytosol Polycystin Complex Metanephric Smooth Muscle Tissue Development Renal Artery Morphogenesis Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Metanephric Part Of Ureteric Bud Development Regulation Of Sequestering Of Calcium Ion Migrasome Metanephric Ascending Thin Limb Development Distal Tubule Development Cellular Response To Hydrostatic Pressure HLH Domain Binding Metanephric S-shaped Body Morphogenesis Detection Of Nodal Flow NF-kappaB Complex Calcium-induced Calcium Release Activity Basal Cortex Nephric Duct Development Mesonephric Duct Development Sensory Perception Of Bitter Taste Glutamate Biosynthetic Process S-shaped Body Morphogenesis Determination Of Liver Left/right Asymmetry Response To Hydrostatic Pressure Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Kinetochore Binding Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metanephric Mesenchyme Development Phosphatidylinositol Phospholipase C Activity