SIAH1 and NUMBL

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SIAH1	NUMBL
Name		siah E3 ubiquitin protein ligase 1	NUMB like endocytic adaptor protein
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Beta-catenin Destruction Complex	Cytoplasm Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Ubiquitination Cell Differentiation Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Nervous System Development Neuroblast Proliferation Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Forebrain Development Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis Regulation Of Postsynapse Assembly
Pathways		Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	None
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 28552196 ) Mean corpuscular hemoglobin ( 32888494 ) Waist circumference ( 28552196 )	Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941 ) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941 ) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941 ) Carotid intima media thickness (mean) ( 31801372 ) Kawasaki disease ( 22446962 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) tricyclic pyrone compound response (IC50) ( 33610756 )
Interacting Genes		157 interacting genes: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 AXIN2 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 COPS5 DAB1 DAZAP2 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4C16 HCFC1 HIF1AN HIPK2 HIPK3 INHA IQCN ITSN1 KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NHERF2 NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PCDH17 PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PINK1 PKD1 POU2AF1 PRPF31 PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLAIN1 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX	24 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 UBE3A YWHAG
Entrez ID		6477	9253
HPRD ID		03736	04931
Ensembl ID		ENSG00000196470	ENSG00000105245
Uniprot IDs		Q8IUQ4	A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0
PDB IDs		2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ 8HEO 9G0L	3F0W
GO Terms Enriched among Interactors		Nucleus Ubiquitin Conjugating Enzyme Activity Protein Binding Ubiquitin Protein Ligase Binding Nucleoplasm Cytoplasm Protein Modification By Small Protein Conjugation Protein Polyubiquitination Perinuclear Region Of Cytoplasm Microtubule Cytoskeleton Post-translational Protein Modification Identical Protein Binding Beta-catenin Destruction Complex Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Nuclear Body Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Nucleotide Binding Protein Ubiquitination Cell Death Microtubule-based Process Apoptotic Process SUMO Transferase Activity Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Microtubule Regulation Of Macromolecule Metabolic Process Microtubule Binding Organelle Organization Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Lateral Ventricle Development Astrocyte Projection Positive Regulation Of Post-translational Protein Modification Establishment Of Mitochondrion Localization UBC13-MMS2 Complex Neuroblast Division In Subventricular Zone Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Adenyl-nucleotide Exchange Factor Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process	Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Interleukin-17-mediated Signaling Pathway Positive Regulation Of Signal Transduction Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Phosphate Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Amyloid Fibril Formation Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Protein Phosphorylation Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Developmental Process Positive Regulation Of MAPK Cascade Regulation Of Cell Population Proliferation Protein Polyubiquitination Positive Regulation Of Metabolic Process Regulation Of Cell Communication Endosome Membrane Positive Regulation Of Apoptotic Signaling Pathway Macromolecule Catabolic Process Regulation Of Apoptotic Process Canonical NF-kappaB Signal Transduction Cytosol Tumor Necrosis Factor-mediated Signaling Pathway CD40 Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process CD40 Receptor Complex Regulation Of Primary Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Receptor Complex Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Signaling Adaptor Activity Positive Regulation Of Cell Population Proliferation