SIAH1 and AFF4

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid), HPRD (two hybrid)

		SIAH1	AFF4
Name		siah E3 ubiquitin protein ligase 1	ALF transcription elongation factor 4
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Beta-catenin Destruction Complex	Euchromatin Fibrillar Center Nucleus Nucleoplasm Chromosome Transcription Elongation Factor Complex Nuclear Body Super Elongation Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Ubiquitination Cell Differentiation Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Spermatid Development Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress
Pathways		Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 28552196 ) Mean corpuscular hemoglobin ( 32888494 ) Waist circumference ( 28552196 )	A body shape index ( 34021172 ) Asthma ( 31619474 ) Estimated glomerular filtration rate ( 31152163 ) Itch intensity from mosquito bite ( 28199695 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		157 interacting genes: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 AXIN2 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 COPS5 DAB1 DAZAP2 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4C16 HCFC1 HIF1AN HIPK2 HIPK3 INHA IQCN ITSN1 KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NHERF2 NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PCDH17 PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PINK1 PKD1 POU2AF1 PRPF31 PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLAIN1 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX	10 interacting genes: AP2B1 BTG3 CCNT1 CDK9 GOLGA2 LRRK2 MLLT1 SIAH1 SPP1 TRAF2
Entrez ID		6477	27125
HPRD ID		03736	09187
Ensembl ID		ENSG00000196470	ENSG00000072364
Uniprot IDs		Q8IUQ4	Q9UHB7
PDB IDs		2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ 8HEO 9G0L	4IMY 4OGR 4OR5 5JW9 5L1Z 6CYT 6K7P 6KN5 6R80
GO Terms Enriched among Interactors		Nucleus Ubiquitin Conjugating Enzyme Activity Protein Binding Ubiquitin Protein Ligase Binding Nucleoplasm Cytoplasm Protein Modification By Small Protein Conjugation Protein Polyubiquitination Perinuclear Region Of Cytoplasm Microtubule Cytoskeleton Post-translational Protein Modification Identical Protein Binding Beta-catenin Destruction Complex Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Nuclear Body Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Nucleotide Binding Protein Ubiquitination Cell Death Microtubule-based Process Apoptotic Process SUMO Transferase Activity Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Microtubule Regulation Of Macromolecule Metabolic Process Microtubule Binding Organelle Organization Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Lateral Ventricle Development Astrocyte Projection Positive Regulation Of Post-translational Protein Modification Establishment Of Mitochondrion Localization UBC13-MMS2 Complex Neuroblast Division In Subventricular Zone Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Adenyl-nucleotide Exchange Factor Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process	P-TEFb Complex 7SK SnRNA Binding Cyclin/CDK Positive Transcription Elongation Factor Complex SnRNA Binding Host-mediated Activation Of Viral Transcription Transcription Elongation Factor Complex Protein Kinase Binding Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Clathrin Binding Positive Regulation Of Biosynthetic Process Host-mediated Activation Of Viral Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury TORC2 Complex Disassembly Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Host-mediated Perturbation Of Viral Process Positive Regulation Of Protein Modification Process Negative Regulation Of Catabolic Process Positive Regulation Of Estradiol Secretion TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Protein Modification Process Regulation Of Apoptotic Signaling Pathway Regulation Of Transcription Elongation By RNA Polymerase II Cytoplasmic Side Of Plasma Membrane Regulation Of DNA-templated Transcription Elongation Host-mediated Perturbation Of Symbiont Process Positive Regulation Of Protein Localization To Chromatin Negative Regulation Of Autophagy Canonical Wnt Signaling Pathway Regulation Of Estradiol Secretion Positive Regulation Of Protein Autoubiquitination Response To Curcumin Signal Sequence Binding Chromatin Binding Regulation Of Protein Serine/threonine Kinase Activity