CREB3L2 and GCFC2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CREB3L2	GCFC2
Name		cAMP responsive element binding protein 3 like 2	GC-rich sequence DNA-binding factor 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Nucleoplasm Nucleolus Cytosol U2-type Post-mRNA Release Spliceosomal Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity CAMP Response Element Binding	DNA Binding Protein Binding
	Biological Process	Chondrocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		CREB3 factors activate genes	mRNA Splicing - Major Pathway
GWAS		A body shape index ( 34021172 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) LDL cholesterol levels ( 30698716 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 ) Pulse pressure ( 27841878 ) Refractive error ( 32231278 ) Total cholesterol levels ( 31217584 ) Waist circumference adjusted for body mass index ( 34021172 )	Chronotype ( 30696823 ) Depression in multiple sclerosis (post-diagnosis) ( 33296963 ) Hippocampal atrophy ( 22745009 )
Interacting Genes		10 interacting genes: CEP19 GABARAPL1 GAS7 GCFC2 GULP1 PTP4A1 PXN RGS16 RND1 ZNF212	4 interacting genes: ATXN1 CREB3L2 RNF10 TFIP11
Entrez ID		64764	6936
HPRD ID		16391	01791
Ensembl ID		ENSG00000182158	ENSG00000005436
Uniprot IDs		Q70SY1	A4UHR0 B3KUM5 P16383 Q9BVX3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Regulation Of Glial Cell Proliferation Regulation Of Gliogenesis Poly(G) Binding Regulation Of Nucleobase-containing Compound Metabolic Process POZ Domain Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Spliceosomal Complex Disassembly Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Protection From Non-homologous End Joining At Telomere U2-type Post-mRNA Release Spliceosomal Complex Nuclear Inclusion Body Regulation Of Neurogenesis CAMP Response Element Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Telomere Maintenance In Response To DNA Damage Regulation Of Nervous System Development Negative Regulation Of Glial Cell Proliferation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Myelination Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway