SMYD3 and H3-5

Number of citations: 0 (PubMedID 23455924)
Data Source: BioGRID (two hybrid)

		SMYD3	H3-5
Name		SET and MYND domain containing 3	H3.5 histone
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Myotube Cell Development Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus	Positive Regulation Of Cell Growth
Pathways		PKMTs methylate histone lysines	None
GWAS		Bipolar disorder ( 31043756 ) Blood metabolite levels ( 26401656 ) Coffee consumption ( 31046077 ) DHEAS levels ( 34748635 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) Gut microbiota relative abundance (Bifidobacterium) ( 33208821 ) Malaria ( 31844061 ) Obesity-related traits ( 23251661 ) Post bronchodilator FEV1 ( 26634245 ) PR interval ( 32439900 ) Renal underexcretion gout ( 32238385 ) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319 ) Systemic lupus erythematosus ( 29848360 ) Upper eyelid sagging severity ( 24869959 )	No GWAS studies recorded
Interacting Genes		25 interacting genes: APP CAMK2B CFTR CSTF2T CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 LCOR MAP3K2 MKRN3 NDUFAB1 NFYB NUP54 PBX2 PKN1 POLR2K RNF113A SHC3 TRIT1 VANGL1 ZNF557	15 interacting genes: DAXX DNAJC9 FBLIM1 KAT6A KDM1A KDM4B NASP NSD3 PRMT5 PRMT6 PRMT7 SETMAR SMYD1 SMYD3 SUV39H1
Entrez ID		64754	440093
HPRD ID		12297	18443
Ensembl ID		ENSG00000185420	ENSG00000188375
Uniprot IDs		B3KN46 Q9H7B4	Q6NXT2
PDB IDs		3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL 6O9O 6P6G 6P6K 6P7Z 6PAF 6YUH 6ZRB 7BJ1 7O2A 7O2B 7O2C 7QLB 7QNR 7QNU 8OWO	2PUY 3KV4 4Z5T 5BWN 5BWO 5F6K 5I3L 6OI3 7TRL 7W67 7W6I 7W6J 7W6L 7Y0I 7ZEZ 8Q1G 8Q1H 8Q1J 8RBX 8SR6 8T4F 8T4R 8ZXC 9C0O 9DZN
GO Terms Enriched among Interactors		Nucleus Pronucleus Transcription Corepressor Binding Chromatin Silencing Complex	Chromatin Remodeling Chromatin Organization Histone Methyltransferase Activity Methyltransferase Activity Methylation Histone H3 Methyltransferase Activity Histone H4R3 Methyltransferase Activity Nucleosome Assembly Protein-arginine N-methyltransferase Activity Nucleosome Organization Histone Binding Histone H3K4 Methyltransferase Activity Protein-DNA Complex Assembly Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Transferase Activity Regulation Of Signal Transduction By P53 Class Mediator Histone H3K36 Dimethyltransferase Activity Nucleoplasm Peptidyl-arginine Methylation Protein-arginine Omega-N Monomethyltransferase Activity Nucleus Chromosome Histone H4 Methyltransferase Activity Transcription Corepressor Activity Histone H3K4 Trimethyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Histone H3K36 Methyltransferase Activity Histone H3K9 Demethylase Activity Protein-containing Complex Assembly Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Regulation Of RNA Metabolic Process Positive Regulation Of ATP-dependent Activity Histone Demethylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Nuclear Androgen Receptor Binding Histone Methyltransferase Complex S-adenosylmethionine-dependent Methyltransferase Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP-dependent Activity