SMURF2 and TFPI2

Number of citations: 54 (PubMedID 15231748)
Data Source: HPRD (two hybrid)

		SMURF2	TFPI2
Name		SMAD specific E3 ubiquitin protein ligase 2	tissue factor pathway inhibitor 2
Structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Membrane Raft	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Blood Coagulation Hemostasis
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Developmental Lineage of Pancreatic Ductal Cells
GWAS		Cardiac troponin-I levels ( 31014085 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Joint mobility (Beighton score) ( 27182965 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Periodontitis (Mean PAL) ( 24024966 )	Heart rate response to recovery post exercise (10 sec) ( 29497042 ) Heart rate response to recovery post exercise (20 sec) ( 29497042 ) Heart rate response to recovery post exercise (30 sec) ( 29497042 ) Heart rate response to recovery post exercise (40 sec) ( 29497042 ) Heart rate response to recovery post exercise (50 sec) ( 29497042 )
Interacting Genes		94 interacting genes: ABRAXAS2 ACBD3 ACOX3 ADAR AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 DSCR9 EGFR EPHA1 ERBB2 FKBP4 FLNB FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LITATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PARP1 PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOD RLIM RNF11 RNF111 RNF2 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TRIM28 TSSK4 TXNIP UBC UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44	5 interacting genes: F11 KLKB1 PLG SKIL SMURF2
Entrez ID		64750	7980
HPRD ID		06901	08962
Ensembl ID		ENSG00000108854	ENSG00000105825
Uniprot IDs		Q96DE7 Q9HAU4	P48307
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4 7M3Q	1ZR0
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Binding I-SMAD Binding Heteromeric SMAD Protein Complex Response To Growth Factor Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Protein-containing Complex Negative Regulation Of RNA Metabolic Process GTPase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process GDP Binding Negative Regulation Of Transcription By RNA Polymerase II GTP Binding Nucleoplasm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytosol Negative Regulation Of Signal Transduction SMAD Protein Complex Cell Surface Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Cell Development Regulation Of RNA Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Transcription Regulator Complex Ureteric Bud Development Negative Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Response To Transforming Growth Factor Beta Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Osteoblast Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Mesonephric Tubule Development Cellular Developmental Process Intracellular Signal Transduction Mesonephric Epithelium Development Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding	Positive Regulation Of Fibrinolysis Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Coagulation Blood Coagulation Hemostasis Plasminogen Activation Serine-type Peptidase Activity Regulation Of Wound Healing Serine-type Endopeptidase Activity Fibrinolysis Regulation Of Response To Wounding Protein Processing Zymogen Activation Regulation Of Body Fluid Levels Protein Maturation SMAD Binding Negative Regulation Of BMP Signaling Pathway Proteolysis Peptidase Activity Serine-type Aminopeptidase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Extracellular Space Factor XII Activation Regulation Of Multicellular Organismal Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Trans-synaptic Signaling By BDNF Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Protein Domain Specific Binding Protein Antigen Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Trophoblast Giant Cell Differentiation Lens Fiber Cell Differentiation Negative Regulation Of Multicellular Organismal Process Regulation Of Cellular Response To Growth Factor Stimulus Plasma Membrane