SMURF2 and RAB14

Number of citations: 0 (PubMedID 15761153)
Data Source: HPRD (in vivo)

		SMURF2	RAB14
Name		SMAD specific E3 ubiquitin protein ligase 2	RAB14, member RAS oncogene family
Structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Membrane Raft	Golgi Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Rough Endoplasmic Reticulum Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Cilium Endomembrane System Membrane Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Phagolysosome Assembly Intracellular Protein Transport Golgi To Endosome Transport Fibroblast Growth Factor Receptor Signaling Pathway Protein Transport Vesicle-mediated Transport Endocytic Recycling Regulation Of Protein Localization Endosomal Vesicle Fusion Early Endosome To Golgi Transport Defense Response To Bacterium Regulation Of Embryonic Development Intracellular Transport Phagosome Maturation
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
GWAS		Cardiac troponin-I levels ( 31014085 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Joint mobility (Beighton score) ( 27182965 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Periodontitis (Mean PAL) ( 24024966 )	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 )
Interacting Genes		94 interacting genes: ABRAXAS2 ACBD3 ACOX3 ADAR AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 DSCR9 EGFR EPHA1 ERBB2 FKBP4 FLNB FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LITATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PARP1 PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOD RLIM RNF11 RNF111 RNF2 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TRIM28 TSSK4 TXNIP UBC UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44	13 interacting genes: ADRB2 APP ARL8B CHM EXOC5 GARIN6 OCRL OPTN RAB11FIP5 RBSN RUFY1 SH3BP5L SMURF2
Entrez ID		64750	51552
HPRD ID		06901	06693
Ensembl ID		ENSG00000108854	ENSG00000119396
Uniprot IDs		Q96DE7 Q9HAU4	P61106
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4 7M3Q	1Z0F 4D0G 4DRZ
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Binding I-SMAD Binding Heteromeric SMAD Protein Complex Response To Growth Factor Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Protein-containing Complex Negative Regulation Of RNA Metabolic Process GTPase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process GDP Binding Negative Regulation Of Transcription By RNA Polymerase II GTP Binding Nucleoplasm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytosol Negative Regulation Of Signal Transduction SMAD Protein Complex Cell Surface Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Cell Development Regulation Of RNA Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Transcription Regulator Complex Ureteric Bud Development Negative Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Response To Transforming Growth Factor Beta Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Osteoblast Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Mesonephric Tubule Development Cellular Developmental Process Intracellular Signal Transduction Mesonephric Epithelium Development Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding	Vesicle-mediated Transport Endosome Early Endosome Membrane Early Endosome To Golgi Transport Early Endosome Small GTPase Binding Golgi Vesicle Transport Cellular Response To Amyloid-beta Response To Amyloid-beta Innate Immune Response Response To Mechanical Stimulus Positive Regulation Of CAMP/PKA Signal Transduction Golgi-associated Vesicle Defense Response To Symbiont Defense Response To Gram-negative Bacterium Protein Transport Endosomal Vesicle Fusion Cellular Localization Defense Response To Other Organism Retrograde Transport, Endosome To Golgi Platelet Alpha Granule Post-Golgi Vesicle-mediated Transport Neuronal Dense Core Vesicle Defense Response To Bacterium Lysosomal Transport Establishment Of Protein Localization Cytosolic Transport Recycling Endosome Amyloid Fibril Formation Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Ligand-gated Ion Channel Signaling Pathway Vacuolar Transport Negative Regulation Of Cell Communication Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Signaling Amyloid-beta Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Bacterium Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Blood Coagulation, Common Pathway Membrane Organization Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding