SHB and IL2RB

Number of citations: 0 (PubMedID 12200137)
Data Source: HPRD (in vivo)

		SHB	IL2RB
Name		SH2 domain containing adaptor protein B	interleukin 2 receptor subunit beta
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Ribonucleoprotein Granule	Endosome Cytosol Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Signaling Receptor Complex Adaptor Activity	Cytokine Receptor Activity Interleukin-2 Receptor Activity Protein Binding Coreceptor Activity Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Angiogenesis Blood Vessel Development Apoptotic Process Signal Transduction Hemopoiesis Cell Differentiation B Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Blood Vessel Morphogenesis T Cell Receptor Signaling Pathway Hematopoietic Stem Cell Proliferation Negative Regulation Of Oocyte Maturation	Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Protein-containing Complex Assembly
Pathways		VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway	RAF/MAP kinase cascade Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs		None	Denileukin diftitox Aldesleukin Basiliximab Daclizumab
GWAS		Brain structure ( 20171287 ) Chronotype ( 30696823 ) Loneliness (linear analysis) ( 27629369 ) Longevity (100 years and older) ( 33948810 ) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 ) Type 2 diabetes (age of onset) ( 28060188 )	Asthma ( 20860503 32296059 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) L-selectin levels ( 25576479 ) Lack of premeditation ( 30718321 ) Mean corpuscular volume ( 27863252 ) Rheumatoid arthritis ( 23143596 24390342 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Tuberculosis ( 24057671 ) Type 1 diabetes ( 21829393 )
Interacting Genes		27 interacting genes: ABL1 AR CRK EGFR EPS8 ERBB2 ERBB3 ERBB4 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR KIT LAMTOR5 LAT LCP2 MET PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70	29 interacting genes: CISH EIF3B FYN GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN MTDH PIK3R1 PTPN6 RACK1 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK TRIP13
Entrez ID		6461	3560
HPRD ID		02635	00896
Ensembl ID		ENSG00000107338	ENSG00000100385
Uniprot IDs		Q15464	P14784
PDB IDs		Not available	2B5I 2ERJ 3QAZ 4GS7 5M5E 6E8K 7S2S
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of MAPK Cascade Receptor Complex Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Kinase Activity Plasma Membrane ERBB Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Cell Activation Intracellular Signaling Cassette Cell Migration Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Leukocyte Activation Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Phosphorylation Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Phosphorylation Cell Motility Cellular Developmental Process Phosphorylation ERBB2 Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process T Cell Activation Positive Regulation Of Epithelial Cell Proliferation	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Hemopoiesis Lymphocyte Activation Regulation Of Multicellular Organismal Development Interleukin-15-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Leukocyte Activation Regulation Of Developmental Process Positive Regulation Of Leukocyte Cell-cell Adhesion Interleukin-2-mediated Signaling Pathway Regulation Of Lymphocyte Differentiation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Lymphocyte Activation Cell Activation Positive Regulation Of Lymphocyte Differentiation Interleukin-9-mediated Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Positive Regulation Of Developmental Process Regulation Of Cell Adhesion Cell Differentiation Mononuclear Cell Differentiation Regulation Of Cell Development Growth Hormone Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of T Cell Differentiation Positive Regulation Of Leukocyte Differentiation Leukocyte Differentiation Regulation Of Multicellular Organismal Process T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Signal Transduction Lymphocyte Differentiation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Proliferation Cellular Developmental Process Mononuclear Cell Proliferation Positive Regulation Of T Cell Differentiation Interleukin-7-mediated Signaling Pathway Regulation Of Cell Differentiation Activated T Cell Proliferation