SRSF7 and PCBP2

Number of citations: 47 (PubMedID 8871564)
Data Source: HPRD (two hybrid, in vivo)

		SRSF7	PCBP2
Name		serine and arginine rich splicing factor 7	poly(rC) binding protein 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Membrane Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding LncRNA Binding Promoter-enhancer Loop Anchoring Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor	Immune System Process Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Viral RNA Genome Replication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Negative Regulation Of Defense Response To Virus Defense Response To Virus IRES-dependent Viral Translational Initiation Chromatin Looping CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses
GWAS		No GWAS studies recorded	Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte percentage of white cells ( 27863252 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		20 interacting genes: CCNL2 CDK19 CDK6 CEBPA CPSF6 DUSP11 FBXO7 LUC7L LUC7L2 NEDD4 NXF1 OGT PCBP2 PRPF38A RNPS1 SDCBP SREK1 SRPK1 SRPK2 UBC	45 interacting genes: APOBEC3C BARD1 CASK CEBPA CNBP FLNA FOXP1 FTH1 GAR1 HMGA1 HMGA2 HNRNPD HNRNPK HNRNPL HNRNPR LINC01554 MECOM NKAP OGT PABPC1 PAXIP1 PCBP1 PDIA3 PRPF40A PTBP1 PTBP2 QKI RALYL RBFOX2 RBMX RBPMS SF3B2 SLC7A11 SLU7 SNRPA SRSF3 SRSF7 SUMO2 UBC UTP25 WDR77 WDR83 YBX1 YBX2 YBX3
Entrez ID		6432	5094
HPRD ID		08991	03129
Ensembl ID		ENSG00000115875	ENSG00000197111
Uniprot IDs		C9JAB2 Q16629	A0A384N6B9 Q15366
PDB IDs		2HVZ	2AXY 2JZX 2P2R 2PQU 2PY9
GO Terms Enriched among Interactors		Nucleoplasm Nuclear Speck Nucleus RNA Binding MRNA Metabolic Process MRNA Binding MRNA Processing RNA Metabolic Process Regulation Of RNA Splicing RNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding RNA Splicing Protein-RNA Complex Assembly Regulation Of Cell Cycle U2-type Prespliceosome U1 SnRNP Macromolecule Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Hemopoiesis Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of MRNA Processing Positive Regulation Of Viral Genome Replication MRNA Splice Site Recognition Protein Serine Kinase Activity Cyclin D2-CDK6 Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Formation Of Structure Involved In A Symbiotic Process Interleukin-5 Receptor Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Exon-exon Junction Complex Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Protein Targeting Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Response To Vitamin B2 C/EBP Complex Protein Localization To Lysosome Protein Modification Process Channel Inhibitor Activity	RNA Binding Nucleic Acid Binding MRNA Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process RNA Splicing MRNA Processing RNA Processing Nucleus Regulation Of MRNA Metabolic Process MRNA Metabolic Process Regulation Of MRNA Processing Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Regulation Of RNA Splicing Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleoplasm RNA Splicing, Via Transesterification Reactions Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Cytoplasmic Translation Spliceosomal Complex Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Catalytic Step 2 Spliceosome Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Cytoplasmic Translation Ribonucleoprotein Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II