CENPK and SOX6

Number of citations: 0 (PubMedID 10996314)
Data Source: HPRD (two hybrid, in vitro)

		CENPK	SOX6
Name		centromere protein K	SRY-box transcription factor 6
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Kinetochore Assembly	Cartilage Condensation Chondrocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Muscle Organ Development Spinal Cord Oligodendrocyte Cell Differentiation Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Negative Regulation Of DNA-templated Transcription Cartilage Development Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Deactivation of the beta-catenin transactivating complex
GWAS		Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Diverticular disease ( 30177863 ) Subcortical volume (MOSTest) ( 32665545 )	Adolescent idiopathic scoliosis ( 30395268 ) Alanine aminotransferase levels ( 34315874 33547301 ) Anti-saccade response ( 25387707 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Blond vs. brown/black hair color ( 30531825 ) Blood pressure ( 23972371 ) Bone mineral density ( 24249740 ) Bone mineral density (hip) ( 19801982 ) Bone mineral density (wrist) ( 21104366 ) Caffeine consumption from tea ( 33287642 ) Capecitabine sensitivity ( 22864933 ) Chronotype ( 30696823 ) Coronary artery disease ( 33020668 29212778 ) Cotinine glucuronidation ( 25293881 ) Depression ( 33859377 ) Diastolic blood pressure ( 25249183 30578418 27841878 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Experiencing mood swings ( 29500382 ) Femoral neck bone mineral density ( 22504420 32239398 26367794 29499414 ) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398 ) General factor of neuroticism ( 30867560 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 31562340 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 27863252 ) Hypertension ( 25249183 ) Left-handedness ( 32989287 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Longevity (90 years and older) ( 25199915 ) Lumbar spine bone mineral density ( 26367794 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Mean corpuscular hemoglobin ( 32888494 27863252 29403010 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 32888494 27863252 29403010 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Multisite chronic pain ( 33830993 31194737 ) Neurociticism ( 29500382 ) Neuroticism ( 29255261 ) Obesity and osteoporosis ( 19714249 ) Pulse pressure ( 30578418 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Smoking cessation ( 33082346 ) Systolic blood pressure ( 30578418 27841878 25249183 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Tea consumption ( 31046077 )
Interacting Genes		10 interacting genes: AP1G2 HSPB1 MRFAP1L1 PCBD2 PEX14 RTN4IP1 SOX6 TRIM55 TRIM63 WASHC3	15 interacting genes: CENPK CTBP2 DAZAP2 ERG HDAC1 HNF1B NFIC NFIX POMGNT1 SOX5 SUMO1 SUMO2 SUMO3 TRIP12 ZNF184
Entrez ID		64105	55553
HPRD ID		13323	06267
Ensembl ID		ENSG00000123219	ENSG00000110693
Uniprot IDs		D6RHD3 D6RJF0 Q9BS16	P35712
PDB IDs		7PB4 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH	Not available
GO Terms Enriched among Interactors		Contractile Muscle Fiber	Protein Tag Activity Ubiquitin-like Protein Ligase Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Binding PML Body DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Protein Modification Process Negative Regulation Of Stem Cell Population Maintenance Regulation Of Gene Expression Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Endoderm Development Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Transcription Corepressor Binding Regulation Of DNA Binding Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development DNA Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process