CDH23 and USH1C

Number of citations: 44 (PubMedID 12407180)
Data Source: BioGRID (affinity chromatography technology), HPRD (two hybrid, in vivo, in vitro)

		CDH23	USH1C
Name		cadherin related 23	USH1 protein network component harmonin
Structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Centrosome Plasma Membrane Membrane Catenin Complex Stereocilium Stereocilium Tip Synapse Kinocilium Cochlear Hair Cell Ribbon Synapse Photoreceptor Ribbon Synapse	Photoreceptor Outer Segment Photoreceptor Inner Segment Stereocilia Ankle Link Complex Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Brush Border Cilium Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding	Protein Binding Spectrin Binding
	Biological Process	Calcium Ion Transport Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Visual Perception Sensory Perception Of Sound Locomotory Behavior Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Neuron Projection Development Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Photoreceptor Cell Maintenance Inner Ear Development Sensory Perception Of Light Stimulus Equilibrioception Regulation Of Cytosolic Calcium Ion Concentration Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Stereocilium Organization Cochlea Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	G2/M Transition Of Mitotic Cell Cycle Auditory Receptor Cell Morphogenesis Sensory Perception Of Sound Parallel Actin Filament Bundle Assembly Cell Differentiation Regulation Of Microvillus Length Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Photoreceptor Cell Maintenance Retinal Cone Cell Development Neuromuscular Process Controlling Balance Sensory Perception Of Light Stimulus Equilibrioception Actin Filament Bundle Assembly Inner Ear Receptor Cell Stereocilium Organization Protein-containing Complex Assembly Protein Localization To Microvillus Brush Border Assembly
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Diseases		Deafness, autosomal recessive Usher syndrome (US)	Deafness, autosomal recessive Usher syndrome (US)
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187 ) Age-related hearing impairment ( 34108613 ) Bipolar disorder (body mass index interaction) ( 24322204 ) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835 ) Cognitive performance (processing speed) ( 31598132 ) Decline in glucose metabolism in posterior cingulate cortex ( 29130521 ) Diffusing capacity of the lung for carbon monoxide traits ( 30049742 ) Diisocyanate-induced asthma ( 25918132 ) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) Kidney function decline traits ( 25493955 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 32888494 ) Progranulin levels ( 29186428 ) Selective IgA deficiency ( 27723758 ) Self-reported risk-taking behaviour ( 30271922 ) Systemic lupus erythematosus ( 33272962 33536424 ) Vitiligo ( 22951725 )	Body mass index ( 26426971 ) Macular thickness ( 30535121 ) Night sleep phenotypes ( 27126917 )
Interacting Genes		3 interacting genes: CLK1 MYO7A USH1C	13 interacting genes: ANKS4B CDH23 CTNNAL1 ENKD1 FBXO7 MIPOL1 MYO7A PCDHB12 PRKAA2 QKI RAC1 USH1G USHBP1
Entrez ID		64072	10083
HPRD ID		05699	09241
Ensembl ID		ENSG00000107736	ENSG00000006611
Uniprot IDs		A0A087WYR8 A5D6V9 Q6P152 Q8N5B3 Q9H251	A0A0S2Z4U9 A0A0S2Z4V1 Q9Y6N9
PDB IDs		2KBR 2KBS 2LSR 5TFM 5VVM 5WJ8	1X5N 2KBQ 2KBR 2KBS 2LSR 3K1R 5F3X 5MV8 5MV9 5XBF 7X2E
GO Terms Enriched among Interactors		Equilibrioception Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Spectrin Binding Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Eye Photoreceptor Cell Development Inner Ear Receptor Cell Stereocilium Organization Photoreceptor Cell Development Stereocilium Photoreceptor Inner Segment Inner Ear Morphogenesis Microvillus Photoreceptor Outer Segment Epidermal Cell Differentiation Upper Tip-link Density Myosin VII Complex Sensory Perception Of Sound Sensory Perception Of Mechanical Stimulus Neuron Development Protein Localization To Microvillus Sensory Perception Of Light Stimulus Phagolysosome Assembly Stereocilium Base Actin Filament Organization Brush Border Assembly Regulation Of Microvillus Length Stereocilia Ankle Link Complex Auditory Receptor Cell Morphogenesis Parallel Actin Filament Bundle Assembly Neuron Differentiation Photoreceptor Cell Cilium Epithelial Cell Differentiation Embryonic Morphogenesis Retinal Cone Cell Development Regulation Of Cell Projection Size Sensory Perception Neuron Projection Development Supramolecular Fiber Organization Stereocilium Tip Auditory Receptor Cell Stereocilium Organization Cell Morphogenesis Involved In Neuron Differentiation Pigment Granule Transport Pigment Granule Localization Protein Serine/threonine/tyrosine Kinase Activity Microfilament Motor Activity Cochlea Development ADP Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Photoreceptor Connecting Cilium	Equilibrioception Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Inner Ear Receptor Cell Stereocilium Organization Photoreceptor Inner Segment Inner Ear Morphogenesis Kinocilium Photoreceptor Cell Cilium Auditory Receptor Cell Stereocilium Organization Inner Ear Auditory Receptor Cell Differentiation Neuron Differentiation Hair Cell Differentiation Spectrin Binding Sensory Perception Of Mechanical Stimulus Sensory Perception Of Sound Plasma Membrane Bounded Cell Projection Embryonic Morphogenesis Plasma Membrane Bounded Cell Projection Organization Cochlea Development Neuron Projection Development Sensory Perception Of Light Stimulus Photoreceptor Cell Maintenance Photoreceptor Connecting Cilium Stereocilium Ciliary Base Upper Tip-link Density Cell Differentiation Myosin VII Complex Internal N(7)-methylguanine-containing RNA Reader Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Inner Ear Development Cell Projection Organization Actin Filament-based Movement Microvillus Ciliary Basal Body [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Myofibroblast Contraction Negative Regulation Of MiRNA Catabolic Process Cochlear Hair Cell Ribbon Synapse Protein Localization To Microvillus