DMRTC2 and IRF9

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		DMRTC2	IRF9
Name		DMRT like family C2	interferon regulatory factor 9
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleus	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol ISGF3 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Male Meiosis I Spermatid Nucleus Elongation Sex Differentiation Cell Differentiation Heterochromatin Organization	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus
Pathways		None	Interferon gamma signaling Interferon alpha/beta signaling
GWAS		Brain morphology (MOSTest) ( 32665545 )	No GWAS studies recorded
Interacting Genes		2 interacting genes: IRF9 TXNRD1	20 interacting genes: ARID3B DACH2 DMRTC2 HOXC9 IFNA1 ILF3 IRF1 IRF2BP1 MYO1F NFKB1 NR2E3 POU2F1 RELA S100A13 STAT1 STAT2 TLX2 TLX3 TOP1 VENTX
Entrez ID		63946	10379
HPRD ID		16829	00960
Ensembl ID		ENSG00000142025	ENSG00000213928
Uniprot IDs		B4DX56 Q8IXT2	A0A8V8TMJ8 A0A8V8TP83 H0YNP4 Q00978
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		NADPH Peroxidase Activity ISGF3 Complex Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Thioredoxin-disulfide Reductase (NADPH) Activity	DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Virus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Defense Response To Virus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process NF-kappaB P50/p65 Complex Interferon-mediated Signaling Pathway RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Nucleoplasm ISGF3 Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Response To Peptide Hormone Transcription Coactivator Binding Type I Interferon-mediated Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Nicotine Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Interleukin-12 Production Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Mechanical Stimulus Actinin Binding DNA-templated Transcription Type II Interferon-mediated Signaling Pathway