ZNF335 and CCAR2

Number of citations: 62 (PubMedID 19131338)
Data Source: BioGRID (two hybrid)

		ZNF335	CCAR2
Name		zinc finger protein 335	cell cycle and apoptosis regulator 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Spindle Cytoskeleton DBIRD Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone Methyltransferase Binding	Adenyl-nucleotide Exchange Factor Activity RNA Polymerase II Complex Binding RNA Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding Unfolded Protein Binding
	Biological Process	In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Brain Development Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Cerebral Cortex Neuron Differentiation Epigenetic Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Neuron Projection Morphogenesis Brain Morphogenesis Positive Regulation Of Lymphocyte Proliferation Regulation Of Neurogenesis Positive Regulation Of Neurogenesis	Regulation Of DNA-templated Transcription MRNA Processing Apoptotic Process DNA Damage Response RNA Splicing Response To UV Wnt Signaling Pathway Negative Regulation Of Cell Growth Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Elongation Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Deacetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of DNA Damage Checkpoint
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Regulation of HSF1-mediated heat shock response
GWAS		Abdominal aortic aneurysm ( 27899403 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Celiac disease ( 25920553 ) Coronary artery disease ( 29212778 33020668 ) General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) Myocardial infarction ( 33532862 )	Haemorrhoidal disease ( 33888516 )
Interacting Genes		6 interacting genes: CCAR2 CDK4 CDK6 HSPB2 NCOA6 USP7	20 interacting genes: AR BAG2 CEBPA FMR1 FXR1 FXR2 HTRA2 IKBKB MAILR MALAT1 MYC NLGN3 RNF10 SIAH2 SIRT1 SUCLG1 SUMO2 TRIM28 WDR3 ZNF335
Entrez ID		63925	57805
HPRD ID		11709	09159
Ensembl ID		ENSG00000198026	ENSG00000158941
Uniprot IDs		Q8IW09 Q9H4Z2	Q8N163
PDB IDs		Not available	8EZ6
GO Terms Enriched among Interactors		Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Damage Response Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cyclin D2-CDK6 Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Fibroblast Proliferation Cyclin D1-CDK4 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Unfolded Protein Binding Regulation Of Circadian Rhythm Negative Regulation Of Protein Catabolic Process DBIRD Complex Regulation Of DNA-templated Transcription Cyclin D2-CDK4 Complex Regulation Of RNA Biosynthetic Process Response To Stress Cellular Response To Stress Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Symbiont-mediated Disruption Of Host Cell PML Body Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Cell Cycle Phase Transition Somatic Muscle Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA Damage Checkpoint Cellular Response To Ionomycin Gliogenesis Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi Nucleus	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Translation Regulator Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Development Positive Regulation Of Catabolic Process Regulation Of Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Presynapse Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Developmental Process Regulation Of Nervous System Development Negative Regulation Of Metabolic Process RNA Strand Annealing Activity Positive Regulation Of Nervous System Development Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Molecular Condensate Scaffold Activity Intracellular Membraneless Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Protein Heterodimerization Activity Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ubiquitin-dependent Protein Catabolic Process Euchromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Neurogenesis Protein Catabolic Process Regulation Of Protein Catabolic Process