CXCL12 and VCAN

Number of citations: 0 (PubMedID 11083865)
Data Source: BioGRID (pull down)

		CXCL12	VCAN
Name		C-X-C motif chemokine ligand 12	versican
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Extracellular Matrix Extracellular Exosome	Photoreceptor Outer Segment Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Membrane Extracellular Matrix Interphotoreceptor Matrix Cell Projection Lysosomal Lumen Synapse Perineuronal Net
	Molecular Function	Signaling Receptor Binding Cytokine Activity Integrin Binding Protein Binding Chemokine Activity Growth Factor Activity Chemokine Receptor Binding CXCR Chemokine Receptor Binding	Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Protein Tyrosine Phosphatase Activator Activity Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding
	Biological Process	Response To Hypoxia Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Intracellular Calcium Ion Homeostasis Chemotaxis Defense Response Immune Response Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Axon Guidance Blood Circulation Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Response To Mechanical Stimulus Response To Virus T Cell Chemotaxis Telencephalon Cell Migration Positive Regulation Of Cell Migration Animal Organ Regeneration Killing Of Cells Of Another Organism Positive Regulation Of Dopamine Secretion Integrin Activation Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway CXCL12-activated CXCR4 Signaling Pathway Response To Peptide Hormone Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Chemotaxis Induction Of Positive Chemotaxis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Calcium Ion Transport Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Calcium Ion Import Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Vasculature Development Response To Ultrasound Cellular Response To Chemokine Positive Regulation Of T Cell Migration Negative Regulation Of Dendritic Cell Apoptotic Process	Skeletal System Development Osteoblast Differentiation Cell Adhesion Central Nervous System Development Cell Recognition Glial Cell Migration System Development
Pathways		Nuclear signaling by ERBB4 Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Estrogen-dependent gene expression	Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation
Drugs		CTCE-0214 Tinzaparin	Hyaluronic acid
Diseases		None	Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Anti-drug antibodies in autoimmune disease (time to event) ( 33125391 ) Blood protein levels ( 30072576 ) Body mass index ( 25760438 ) Coronary artery disease ( 32469254 24262325 26708285 26343387 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 17634449 21378990 ) Diastolic blood pressure ( 27841878 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Granulocyte count ( 27863252 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676 ) Lymphocyte count ( 32888494 ) Monocyte count ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Myocardial infarction ( 26343387 33532862 ) Myocardial infarction (early onset) ( 19198609 ) Neutrophil count ( 27863252 32888494 ) QT interval (ambient particulate matter interaction) ( 28749367 ) Red blood cell count ( 32888494 ) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous) ( 28628665 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 ) Schizophrenia ( 23212062 ) Smoking initiation (ever regular vs never regular) ( 31089300 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 27863252 32888494 )	Appendicular lean mass ( 33097823 28724990 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (MOSTest) ( 32665545 ) Carotid intima media thickness (mean) ( 31801372 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical volume ( 32963231 ) Diisocyanate-induced asthma ( 25918132 ) Gastroesophageal reflux disease ( 31527586 ) HDL cholesterol levels ( 32203549 ) Joint mobility (Beighton score) ( 27182965 ) Laryngeal squamous cell carcinoma ( 25194280 ) Lean body mass ( 28724990 ) Major depressive disorder ( 20516156 ) Optic disc size ( 31809533 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 32203549 ) Vertical cup-disc ratio ( 28073927 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) White matter hyperintensity volume ( 29752348 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter integrity (fractional anisotropy) ( 29752348 32358547 ) White matter integrity (mean diffusivity) ( 29752348 32358547 )
Interacting Genes		30 interacting genes: CCL11 CCL13 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CD4 CTSG CXCL10 CXCL11 CXCL14 CXCL17 CXCL2 CXCL6 CXCL9 CXCR4 DAZAP2 DPP4 ELANE FBXO7 FN1 MMP2 PF4 PF4V1 PPBP VCAN XCL1 XCL2	24 interacting genes: ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A PTPRF RAB19 SELL SELP SELPLG TNR XCL1
Entrez ID		6387	1462
HPRD ID		02904	00340
Ensembl ID		ENSG00000107562	ENSG00000038427
Uniprot IDs		P48061	P13611 Q59FG9 Q86W61
PDB IDs		1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2N55 2NWG 2SDF 3GV3 3HP3 4LMQ 4UAI 6SHR 7SK3 7SK4 7SK5 7SK6 7SK7 7SK8 8K3Z 8U4O	Not available
GO Terms Enriched among Interactors		Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Leukocyte Chemotaxis Leukocyte Migration Cell Migration Humoral Immune Response Cytokine Activity Myeloid Leukocyte Migration Cell Motility Killing Of Cells Of Another Organism Granulocyte Chemotaxis Inflammatory Response Granulocyte Migration Cell Killing Chemokine-mediated Signaling Pathway Defense Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism Extracellular Space Response To Other Organism Immune Response Response To External Biotic Stimulus Mononuclear Cell Migration Extracellular Region Cytokine-mediated Signaling Pathway CXCR Chemokine Receptor Binding CCR Chemokine Receptor Binding Response To Stress Regulation Of Locomotion Neutrophil Chemotaxis Regulation Of Cell Migration Neutrophil Migration Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Binding Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway CXCR3 Chemokine Receptor Binding Response To Molecule Of Bacterial Origin Signal Transduction Cellular Response To Lipid	Leukocyte Migration Chemokine Activity Cell Migration Cell Motility Positive Regulation Of Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of T Cell Migration Regulation Of Lymphocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Lymphocyte Migration Positive Regulation Of Locomotion Regulation Of Leukocyte Migration Regulation Of T Cell Migration Antimicrobial Humoral Response Positive Regulation Of Mononuclear Cell Migration Cell Adhesion Leukocyte Cell-cell Adhesion Mononuclear Cell Migration Inflammatory Response Extracellular Space Regulation Of Cell Migration Killing Of Cells Of Another Organism Cell Chemotaxis Cytokine Activity Regulation Of Cell Motility Granulocyte Chemotaxis Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Regulation Of Locomotion Regulation Of Mononuclear Cell Migration Heparin Binding Granulocyte Migration Humoral Immune Response Extracellular Region Leukocyte Tethering Or Rolling Cell Killing Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Adhesion CCR Chemokine Receptor Binding Chemotaxis Myeloid Leukocyte Migration Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Locomotion Chemokine Receptor Binding Regulation Of Leukocyte Cell-cell Adhesion Response To Cytokine Response To Peptide