SDC1 and LACRT

Number of citations: 44 (PubMedID 16982797)
Data Source: HPRD (in vitro)

		SDC1	LACRT
Name		syndecan 1	lacritin
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Secretory Granule
	Molecular Function	Protein Binding Cargo Receptor Activity Identical Protein Binding	Protein Binding Collagen Binding Growth Factor Activity Laminin-1 Binding
	Biological Process	Receptor-mediated Endocytosis Cell Migration Myoblast Development Striated Muscle Cell Development Canonical Wnt Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly	Positive Regulation Of Cell Population Proliferation Epithelial Structure Maintenance Positive Regulation Of Macroautophagy Calcium-mediated Signaling Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Calcineurin-NFAT Signaling Cascade Protein Localization To Golgi Apparatus Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Tear Secretion Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Other interleukin signaling Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	None
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 28892062 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) LDL cholesterol levels ( 32203549 ) Seasonality ( 25562672 ) Triglyceride levels ( 32203549 )	No GWAS studies recorded
Interacting Genes		17 interacting genes: APP CASK CCL5 CD63 CTSG CXCL8 ELANE FGF2 HGF IGFBP7 LACRT MDK MMP14 PTEN PTN SDCBP UBC	6 interacting genes: APP FN1 NID1 SDC1 TGM2 VTN
Entrez ID		6382	90070
HPRD ID		01718	06302
Ensembl ID		ENSG00000115884	ENSG00000135413
Uniprot IDs		P18827	Q9GZZ8
PDB IDs		4GVC 4GVD 6EJE	Not available
GO Terms Enriched among Interactors		Extracellular Space Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Heparin Binding Cell Migration Extracellular Region Chemotaxis Cell Motility Regulation Of Chemotaxis Locomotion Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Chemotaxis Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Chemoattractant Activity Regulation Of Cell Adhesion Positive Regulation Of Leukocyte Chemotaxis Cell Chemotaxis Leukocyte Migration Positive Chemotaxis Leukocyte Chemotaxis Growth Factor Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Response To Wounding Leukocyte Migration Involved In Inflammatory Response Response To Auditory Stimulus Positive Regulation Of Multicellular Organismal Process Response To Mechanical Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Macrophage Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Neutrophil Activation Positive Regulation Of Immune System Process Negative Regulation Of Signal Transduction Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process	Peptidase Activator Activity Golgi Lumen Extracellular Region Extracellular Exosome Collagen Binding Extracellular Matrix Basement Membrane Cell-matrix Adhesion Protein Complex Involved In Cell-matrix Adhesion Extracellular Matrix Structural Constituent Positive Regulation Of Cell-substrate Adhesion Proteoglycan Binding Positive Regulation Of Integrin-mediated Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Integrin Binding Cellular Response To Catecholamine Stimulus Regulation Of Vesicle-mediated Transport Heparin Binding Cell-substrate Adhesion Response To Catecholamine Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Extracellular Matrix Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Adhesion Endodermal Cell Differentiation Cell Adhesion Positive Regulation Of Cell Differentiation Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Platelet Alpha Granule Lumen Positive Regulation Of Cellular Component Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Vesicle-mediated Transport Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity