SCN1B and NFASC

Number of citations: 32 (PubMedID 11470829)
Data Source: HPRD (in vivo)

		SCN1B	NFASC
Name		sodium voltage-gated channel beta subunit 1	neurofascin
Structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Extracellular Region Plasma Membrane Intercalated Disc Membrane T-tubule Axon Node Of Ranvier Sodium Channel Complex Cell Projection Perikaryon	Plasma Membrane Focal Adhesion Membrane Axon Paranodal Junction Node Of Ranvier Axon Initial Segment Anchoring Junction Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding	Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Regulation Of Sodium Ion Transport Monoatomic Ion Transport Sodium Ion Transport Cell Adhesion Axon Guidance Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Corticospinal Neuron Axon Guidance Neuron Projection Development Sodium Ion Transmembrane Transport Locomotion Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Voltage-gated Sodium Channel Activity	Cell Adhesion Axon Guidance Brain Development Peripheral Nervous System Development Myelination Cell-cell Adhesion
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste	Interaction between L1 and Ankyrins Neurofascin interactions Neurofascin interactions Neutrophil degranulation
Drugs		Ranolazine Phenytoin Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil	None
Diseases		Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Brugada syndrome (BRS)	None
GWAS		Metabolite levels ( 23823483 ) Serum albumin levels ( 23022100 )	Age at first sexual intercourse ( 34211149 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blood protein levels ( 30072576 ) Clozapine-induced agranulocytosis ( 25187353 ) Dental caries ( 23064961 ) Diisocyanate-induced asthma ( 25918132 ) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083 ) General risk tolerance (MTAG) ( 30643258 ) High myopia ( 32428537 ) Mean platelet volume ( 27863252 32888494 ) Platelet count ( 32888494 ) Regular attendance at a religious group ( 29970889 )
Interacting Genes		6 interacting genes: ADRA1A ANK3 C5AR2 F2RL1 NFASC SCN2B	12 interacting genes: ABI1 ABI2 ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR
Entrez ID		6324	23114
HPRD ID		02581	12372
Ensembl ID		ENSG00000105711	ENSG00000163531
Uniprot IDs		A0A1W2PR05 Q07699	A0A7P0Z4R6 B4DRH7 O94856
PDB IDs		6AGF 6J8G 6J8H 6J8I 6J8J 7W77 7W7F 7W9K 7W9L 7W9M 7W9P 7W9T 7XM9 7XMF 7XMG 7XVE 7XVF 8FHD 8G1A 8GZ1 8GZ2 8I5B 8I5G 8I5X 8I5Y 8J4F 8S9B 8S9C 8THG 8THH 8XMM 8XMN 8XMO	3P3Y 3P40
GO Terms Enriched among Interactors		Node Of Ranvier Axon Initial Segment Positive Regulation Of Cytosolic Calcium Ion Concentration Sodium Channel Regulator Activity Positive Regulation Of Sodium Ion Transport T-tubule Regulation Of Membrane Depolarization Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure G Protein-coupled Receptor Activity Regulation Of Membrane Potential Plasma Membrane Axon Basal Plasma Membrane Regulation Of Sodium Ion Transport Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Response To Pyrethroid Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of Biological Quality Phospholipase C-activating Adrenergic Receptor Signaling Pathway Regulation Of System Process Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Action Potential Maintenance Of Protein Location In Plasma Membrane Proteinase-activated Receptor Activity Regulation Of Interleukin-8 Production Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Complement Component C5a Receptor Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Interleukin-6 Production Positive Regulation Of Killing Of Cells Of Another Organism Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Complement Component C5a Signaling Pathway Regulation Of Blood Pressure G Protein-coupled Receptor Signaling Pathway Neuron-glial Cell Signaling Positive Regulation Of ERK1 And ERK2 Cascade	Action Potential Propagation Neuronal Action Potential Propagation Cytoskeletal Anchor Activity Action Potential System Development Neuron Migration Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Sodium Channel Inhibitor Activity Sodium Channel Complex Actin-based Cell Projection Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Nervous System Development SCAR Complex Cell Projection Morphogenesis Voltage-gated Sodium Channel Complex Membrane Depolarization During Cardiac Muscle Cell Action Potential SH3 Domain Binding Filopodium Tip Neuron Projection Membrane Depolarization During Action Potential Sodium Ion Transmembrane Transport Transmembrane Transporter Binding Central Nervous System Development Regulation Of Neuron Projection Development Regulation Of Membrane Potential Cell Migration Nervous System Process Cell Junction Organization System Process Sodium Channel Regulator Activity Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Neuron Projection Development Sodium Channel Activity Cardiac Muscle Cell Action Potential Involved In Contraction Cytoskeleton Organization Muscle Contraction Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Cardiac Muscle Contraction Neuron Projection Guidance Axon Guidance Cell Motility Cardiac Conduction Neuromuscular Process Controlling Balance Regulation Of Cellular Component Organization Regulation Of Membrane Depolarization Membrane Depolarization Synapse Organization