RYR3 and HNF1A

Number of citations: 57 (PubMedID 20195357)
Data Source: BioGRID (pull down)

		RYR3	HNF1A
Name		ryanodine receptor 3	HNF1 homeobox A
Structure
GO Annotations	Cellular Component	Smooth Endoplasmic Reticulum Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma	Chromatin Nucleus Cytoplasm Protein-containing Complex
	Molecular Function	Monoatomic Ion Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Calmodulin Binding Intracellularly Gated Calcium Channel Activity Calcium-induced Calcium Release Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Striated Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Magnesium Ion Cellular Response To Caffeine Cellular Response To ATP	Liver Development Regulation Of Transcription By RNA Polymerase II Insulin Secretion Pancreas Development Regulation Of Pronephros Size Renal D-glucose Absorption Glucose Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II D-glucose Import Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Stimuli-sensing channels Ion homeostasis	Regulation of gene expression in beta cells
Drugs		None	D-norleucine
Diseases		None	Maturity onset diabetes of the young (MODY)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Carotid atherosclerosis in HIV infection ( 20009918 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Hepcidin/ferritin ratio ( 27846281 ) Hippocampal volume ( 31530798 ) Malaria ( 31844061 ) Parkinson's disease progression (cognitive) ( 33958783 ) Periodontitis (Mean PAL) ( 24024966 ) Schizophrenia ( 30285260 ) Urinary albumin excretion ( 32277301 )	Acute insulin response ( 28490609 ) Age at first birth ( 34211149 ) Apolipoprotein B levels ( 32203549 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Birth weight ( 31043758 ) Blood protein levels in cardiovascular risk ( 28369058 ) Blood urea nitrogen levels ( 29403010 ) C-reactive protein ( 18439548 18439552 19567438 21196492 21647738 22939635 23844046 ) C-reactive protein and white blood cell count ( 22788528 ) C-reactive protein levels ( 21300955 24763700 29403010 29878111 30388399 31622379 33339817 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809 ) Ceramide levels (C22:0) ( 32489964 ) Chloride levels ( 29403010 ) Cholesterol, total ( 20686565 24097068 25961943 ) Chronic obstructive pulmonary disease-related biomarkers ( 23144326 ) Coronary artery disease ( 28714974 29212778 32469254 33020668 ) Coronary heart disease ( 19198612 ) Gallstone disease ( 30504769 ) Gamma glutamyl transferase levels ( 22010049 29403010 33339817 ) Gamma glutamyl transpeptidase ( 21909109 ) Glucosuria ( 30476138 ) Glucosuria (moderate to severe) ( 30476138 ) HDL cholesterol levels ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Hemoglobin levels ( 32327693 ) High-sensitivity C-reactive protein levels in HIV infection ( 33095540 ) Homocysteine levels ( 23824729 ) Insulinogenic index ( 23263489 ) LDL cholesterol ( 19060906 20686565 24097068 25961943 30275531 ) LDL cholesterol levels ( 28334899 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Liver enzyme levels ( 18940312 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 ) Longevity ( 20834067 ) Low density lipoprotein cholesterol levels ( 32154731 33339817 ) Myocardial infarction ( 33532862 ) N-glycan levels ( 21203500 21908519 ) Pancreatic cancer ( 26098869 29422604 ) Pancreatic ductal adenocarcinoma ( 30541042 ) Peak insulin response ( 28490609 ) Serum alkaline phosphatase levels ( 31666285 33339817 33547301 ) Serum alpha1-antitrypsin levels ( 26174136 ) Serum C-reactive protein concentration ( 32928877 ) Serum C-reactive protein concentration in high fat diet ( 32928877 ) Serum C-reactive protein concentration in low fat diet ( 32928877 ) Serum C-reactive protein concentration in non-obese individuals ( 32928877 ) Serum C-reactive protein concentration in obesity ( 32928877 ) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877 ) Serum C-reactive protein concentration in visceral obesity (waist-hip ratio) ( 32928877 ) Serum metabolite levels (CMS) ( 31636271 ) Stroke ( 32693751 ) Total cholesterol levels ( 28334899 30275531 ) Type 2 diabetes ( 20581827 21573907 22885922 24509480 26818947 28869590 29632382 30297969 30718926 32499647 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Urate levels ( 23263486 31578528 ) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659 )
Interacting Genes		7 interacting genes: BCL2L1 FKBP1A FKBP1B HNF1A RYR2 SRI TIAM1	24 interacting genes: ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B MYOG NCOA1 NCOA3 PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1 TLE5
Entrez ID		6263	6927
HPRD ID		01620	00800
Ensembl ID		ENSG00000198838	ENSG00000135100
Uniprot IDs		A0A0U1RRH1 Q15413	A0A0A0MTK8 E0YMI7 F5H0K0 P20823
PDB IDs		4ERV 6UHA 6UHB 6UHE 6UHH	1IC8 2GYP 8PI7 8PI8 8PI9 8PIA
GO Terms Enriched among Interactors		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Sequestering Of Calcium Ion Z Disc Transmembrane Transporter Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Muscle Contraction Regulation Of Heart Contraction Calcium Channel Regulator Activity Regulation Of Calcium Ion Transport Regulation Of Muscle System Process Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Metal Ion Transport FK506 Binding 'de Novo' Protein Folding Regulation Of Heart Rate Negative Regulation Of Heart Rate Regulation Of Monoatomic Ion Transport Response To Redox State Negative Regulation Of Heart Contraction Calcium-mediated Signaling Regulation Of System Process Negative Regulation Of Blood Circulation Calcium Channel Complex Protein Refolding Regulation Of Cardiac Muscle Cell Contraction Peptidyl-prolyl Cis-trans Isomerase Activity Cellular Response To Alkaloid Calcium Ion Transport Regulation Of Transport Ventricular Cardiac Muscle Tissue Morphogenesis Epithelial Cell Apoptotic Process Insulin Secretion Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Protein Localization Cardiac Muscle Tissue Morphogenesis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Peptide Hormone Secretion	Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Protein-lysine-acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Transcription Coactivator Activity DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Response To Nutrient Levels RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Cellular Response To Nutrient Levels Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Animal Organ Development Positive Regulation Of Cell Differentiation Cellular Response To Oxygen-containing Compound Sequence-specific DNA Binding Nucleus DNA-binding Transcription Factor Activity Chromatin Binding Developmental Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding