RRAD and TPM2

Number of citations: 0 (PubMedID 8557685)
Data Source: HPRD (in vivo, in vitro)

		RRAD	TPM2
Name		RRAD, Ras related glycolysis inhibitor and calcium channel regulator	tropomyosin 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton
	Molecular Function	Nucleotide Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Small GTPase-mediated Signal Transduction	Muscle Contraction Actin Filament Organization Regulation Of ATP-dependent Activity
Pathways		NGF-stimulated transcription	Striated Muscle Contraction Smooth Muscle Contraction
Diseases		None	Cap myopathy Distal arthrogryposis (DA) Nemaline myopathy
GWAS		Waist circumference adjusted for body mass index ( 34021172 )	Immature fraction of reticulocytes ( 32888494 ) Platelet count ( 32888494 ) White blood cell count ( 32888494 )
Interacting Genes		15 interacting genes: CALM1 CAMK2G CCDC141 CSNK2A1 CSNK2B EEA1 EGFR MMP14 NME1 PRKACA PRKCA PRKCB STAT3 TPM2 YWHAZ	22 interacting genes: ABI2 ACTA1 ACTB FARS2 GRK2 JUN MAST2 MESD MRFAP1 NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL SNAPIN TFPT TPM1 ZNF229 ZNF620 ZNF785
Entrez ID		6236	7169
HPRD ID		01536	11768
Ensembl ID		ENSG00000166592	ENSG00000198467
Uniprot IDs		P55042	A7XZE4 P07951 Q5TCU3 V9HW25
PDB IDs		2DPX 2GJS 3Q72 3Q7P 3Q7Q	Not available
GO Terms Enriched among Interactors		Kinase Activity Protein Serine/threonine Kinase Activity Phosphorylation Histone H3T6 Kinase Activity Cytosol Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase C Signaling Regulation Of Protein Localization Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Protein Phosphorylation Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Cytoplasm Regulation Of Signal Transduction Mitotic Nuclear Membrane Disassembly Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Establishment Of Protein Localization Identical Protein Binding Interleukin-2-mediated Signaling Pathway Intracellular Signaling Cassette Regulation Of Muscle System Process Positive Regulation Of Insulin Secretion Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphatase Binding Nuclear Membrane Disassembly ATP Binding Regulation Of Biological Quality Membrane Disassembly Negative Regulation Of Signal Transduction Diacylglycerol-dependent Serine/threonine Kinase Activity Signal Transduction Calyx Of Held Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Estradiol Negative Regulation Of Glycolytic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion	Actin Filament Actin Cytoskeleton Sarcomere Negative Regulation Of Striated Muscle Contraction Stress Fiber Adherens Junction Assembly Identical Protein Binding Structural Constituent Of Cytoskeleton Actin Filament Organization Negative Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Transition Metal Ion Binding Negative Regulation Of Blood Circulation