RPL37 and POLR1B

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		RPL37	POLR1B
Name		ribosomal protein L37	RNA polymerase I subunit B
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Ribosome Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Ribonucleoprotein Complex	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Cytosol
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Zinc Ion Binding RRNA Binding Metal Ion Binding MDM2/MDM4 Family Protein Binding Ubiquitin Ligase Inhibitor Activity	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Ribonucleoside Binding 5'-3' RNA Polymerase Activity Metal Ion Binding DNA/RNA Hybrid Binding
	Biological Process	Cytoplasmic Translation Translation Positive Regulation Of Signal Transduction By P53 Class Mediator	DNA-templated Transcription Embryo Implantation RRNA Transcription Neural Crest Formation Nucleologenesis
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs		(S)-3-phenyllactic acid PUROMYCIN AMINONUCLEOSIDE-5'-MONOPHOSPHATE Virginiamycin S1 Anisomycin Puromycin	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		9 interacting genes: APP CTTN MYO1D POLR1B SQSTM1 SRPK2 TCF3 UBC WIF1	14 interacting genes: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207
Entrez ID		6167	84172
HPRD ID		16047	06852
Ensembl ID		ENSG00000145592	ENSG00000125630
Uniprot IDs		P61927	B7Z1W6 Q9H9Y6
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Neuron Projection Organization Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Intracellular Transport Positive Regulation Of Programmed Cell Death Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Axon Midline Choice Point Recognition Positive Regulation Of Chemotaxis Dendrite Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Regulation Of Long-term Synaptic Potentiation Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Growth Cone Endocytosis Clathrin-coated Pit Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Synaptic Transmission Lipoprotein Particle Positive Regulation Of Cell Cycle Growth Factor Receptor Binding Main Axon Perikaryon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Vesicle-mediated Transport Astrocyte Activation Involved In Immune Response Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Early Endosome To Recycling Endosome Transport Nucleus Organization Nuclear Speck Organization Vitamin D Response Element Binding Brown Fat Cell Proliferation	Macromolecule Biosynthetic Process Transcription Preinitiation Complex Assembly Nucleoplasm DNA-templated Transcription Protein-DNA Complex Assembly Transcription Initiation At RNA Polymerase I Promoter RNA Polymerase I Preinitiation Complex Assembly Nucleobase-containing Compound Biosynthetic Process Regulation Of Intracellular Signal Transduction Protein-containing Complex Organization Mammary Gland Epithelial Cell Proliferation Response To Corticosterone Mammary Gland Alveolus Development Macromolecule Metabolic Process Cellular Component Assembly Enzyme Binding Protein-containing Complex Protein-containing Complex Assembly Response To Mineralocorticoid RNA Metabolic Process Fibroblast Proliferation Cellular Response To High Light Intensity RNA Polymerase II Preinitiation Complex Assembly Transcription Corepressor Binding Spindle Matrix Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation RNA Polymerase I General Transcription Initiation Factor Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Signal Transduction Cell Leading Edge Response To High Light Intensity Response To Hormone Retinal Rod Cell Apoptotic Process Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Response To Estrogen Transcription By RNA Polymerase II Transcription Coactivator Activity Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity DNA-templated Transcription Initiation Cellular Response To Hormone Stimulus Positive Regulation Of Cap-dependent Translational Initiation