RPL37 and WIF1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		RPL37	WIF1
Name		ribosomal protein L37	Wnt inhibitory factor 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Ribosome Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Ribonucleoprotein Complex	Extracellular Region Cell Surface
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Zinc Ion Binding RRNA Binding Metal Ion Binding MDM2/MDM4 Family Protein Binding Ubiquitin Ligase Inhibitor Activity	Signaling Receptor Binding Protein Binding Wnt-protein Binding
	Biological Process	Cytoplasmic Translation Translation Positive Regulation Of Signal Transduction By P53 Class Mediator	Signal Transduction Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Fat Cell Differentiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs		(S)-3-phenyllactic acid PUROMYCIN AMINONUCLEOSIDE-5'-MONOPHOSPHATE Virginiamycin S1 Anisomycin Puromycin	None
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) Dentate gyrus granule cell layer volume ( 30279459 ) Dentate gyrus molecular layer volume ( 30279459 ) Hippocampal fissure volume ( 30279459 ) Hippocampal subfield CA1 volume ( 30279459 ) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459 ) Hippocampal subfield CA3 volume ( 30279459 ) Hippocampal subfield CA4 volume ( 30279459 ) Hippocampal volume ( 22504421 ) Macular thickness ( 30535121 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Subiculum volume ( 30279459 ) Total hippocampal volume ( 30279459 )
Interacting Genes		9 interacting genes: APP CTTN MYO1D POLR1B SQSTM1 SRPK2 TCF3 UBC WIF1	10 interacting genes: AURKA CRADD CYSRT1 DYRK1A FGFR4 ICOS KRTAP10-3 KRTAP10-8 RB1CC1 RPL37
Entrez ID		6167	11197
HPRD ID		16047	05541
Ensembl ID		ENSG00000145592	ENSG00000156076
Uniprot IDs		P61927	Q9Y5W5
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	2D3J 2YGN 2YGO 2YGP 2YGQ
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Neuron Projection Organization Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Intracellular Transport Positive Regulation Of Programmed Cell Death Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Axon Midline Choice Point Recognition Positive Regulation Of Chemotaxis Dendrite Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Regulation Of Long-term Synaptic Potentiation Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Growth Cone Endocytosis Clathrin-coated Pit Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Synaptic Transmission Lipoprotein Particle Positive Regulation Of Cell Cycle Growth Factor Receptor Binding Main Axon Perikaryon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Vesicle-mediated Transport Astrocyte Activation Involved In Immune Response Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Early Endosome To Recycling Endosome Transport Nucleus Organization Nuclear Speck Organization Vitamin D Response Element Binding Brown Fat Cell Proliferation	Protein Autophosphorylation Regulation Of Signal Transduction By P53 Class Mediator Protein Serine/threonine/tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Ribophagy