RPL28 and SGO1

Number of citations: 0 (PubMedID 16541025)
Data Source: HPRD (in vivo)

		RPL28	SGO1
Name		ribosomal protein L28	shugoshin 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Dendrite Cytoplasmic Ribonucleoprotein Granule Cell Body Synapse Extracellular Exosome Ribonucleoprotein Complex	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Protein Binding Kinase Binding
	Biological Process	Cytoplasmic Translation Translation	Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Cell Division Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition EML4 and NUDC in mitotic spindle formation
GWAS		Retinitis pigmentosa ( 33514863 )	No GWAS studies recorded
Interacting Genes		9 interacting genes: CCNDBP1 FNDC3B FOXP1 MAP2K5 PTEN SGO1 SMAD4 STAU1 TMEM230	21 interacting genes: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC PTPA RPL10A RPL28 RPL7 RPL7A RPLP1 SET XRCC5 XRCC6
Entrez ID		6158	151648
HPRD ID		04702	12377
Ensembl ID		ENSG00000108107	ENSG00000129810
Uniprot IDs		H0YKD8 P46779	B5BUA4 Q5FBB7
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKQ 8FKS 8FKU 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO	3FGA 3Q6S 4A0I 7ZJS
GO Terms Enriched among Interactors		Endothelial Cell Activation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Growth Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Growth Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Organ Growth Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Intracellular Signal Transduction Gonad Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Nephrogenic Mesenchyme Morphogenesis Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Growth Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis ERK5 Cascade Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Regulation Of Organ Growth Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Axo-dendritic Transport Positive Regulation Of Interleukin-21 Production Negative Regulation Of Developmental Growth Regulation Of Chemokine Production Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Metanephric Mesenchyme Morphogenesis Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Mitotic Sister Chromatid Cohesion, Centromeric Osteoblast Differentiation Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of System Process Sulfate Binding Endocardial Cell Differentiation Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Smooth Muscle Cell Proliferation	Protein Phosphatase Type 2A Complex Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity Meiotic Sister Chromatid Cohesion Chromosome Organization Cytosolic Large Ribosomal Subunit DNA-dependent Protein Kinase Complex Chromosome, Centromeric Region DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Cytosolic Ribosome Sister Chromatid Cohesion Cytosol Cytoplasmic Translation Nucleus Structural Constituent Of Ribosome FAR/SIN/STRIPAK Complex Chromosome DNA End Binding Ku70:Ku80 Complex Ribosome Small-subunit Processome Assembly Cytoplasm Ribonucleoprotein Complex Meiotic Sister Chromatid Cohesion, Centromeric Protein-DNA Complex 5'-deoxyribose-5-phosphate Lyase Activity Response To Gamma Radiation Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Macromolecule Biosynthetic Process Spindle Organization Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ribonucleoprotein Complex Biogenesis Translation U3 SnoRNA Binding Protein Serine/threonine Phosphatase Activity INTAC Complex Spindle Assembly Response To Lead Ion Telomere Maintenance RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Ribosome Biogenesis Hyperosmotic Response RNA Binding Maturation Of LSU-rRNA Telomeric DNA Binding Cellular Response To Gamma Radiation