RPE and EXOSC10

Number of citations: 47 (PubMedID 15231747)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		RPE	EXOSC10
Name		ribulose-5-phosphate-3-epimerase	exosome component 10
Structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Small-subunit Processome Nucleolar Exosome (RNase Complex)
	Molecular Function	D-ribulose-phosphate 3-epimerase Activity Protein Binding Isomerase Activity Racemase And Epimerase Activity, Acting On Carbohydrates And Derivatives Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Nucleotide Binding 3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Protein Binding 3'-5' Exonuclease Activity Hydrolase Activity Metal Ion Binding Telomerase RNA Binding
	Biological Process	Carbohydrate Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair RRNA Processing RNA Processing RNA Catabolic Process DNA Damage Response Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribosomal Small Subunit Biogenesis Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
Pathways		Pentose phosphate pathway	Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
GWAS		Serum metabolite levels ( 23093944 )	Beard thickness ( 26926045 ) Heel bone mineral density ( 30598549 ) Intraocular pressure ( 29617998 )
Interacting Genes		2 interacting genes: EXOSC10 PLEKHF2	40 interacting genes: ALDH1B1 B9D1 CEBPA CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIC2 SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 USP36 USP7 XRN1 XRN2
Entrez ID		6120	5394
HPRD ID		01608	16180
Ensembl ID		ENSG00000197713	ENSG00000171824
Uniprot IDs		C9IZU8 C9J9T0 Q96AT9	Q01780
PDB IDs		3OVP 3OVQ 3OVR 3QC3	2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R 7MQA
GO Terms Enriched among Interactors		Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Protein Insertion Into Mitochondrial Inner Membrane From Matrix SnRNA Catabolic Process Sno(s)RNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome CUT Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Respiratory Chain Complex III Mitochondrial Respiratory Chain Complex III Assembly RRNA 3'-end Processing Poly(A)-dependent SnoRNA 3'-end Processing Nucleolar Exosome (RNase Complex) TRNA Decay Nuclear MRNA Surveillance Regulation Of Telomerase RNA Localization To Cajal Body Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Histone MRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process 3'-5' Exonuclease Activity Protein Insertion Into Mitochondrial Inner Membrane Maturation Of 5.8S RRNA Mitochondrial Cytochrome C Oxidase Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Respiratory Chain Complex IV Assembly Histone MRNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome 3'-5'-RNA Exonuclease Activity Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane NADH Dehydrogenase Complex Assembly Inner Mitochondrial Membrane Organization Mitochondrial Respiratory Chain Complex I Assembly Cytochrome Complex Assembly Negative Regulation Of Telomere Maintenance Nuclear RNA Surveillance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Surveillance Positive Regulation Of RNA Splicing	Nuclear MRNA Surveillance MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nuclear Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Nuclear RNA Surveillance RNA Catabolic Process RNA Surveillance Cytoplasmic Exosome (RNase Complex) U4 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) MRNA Metabolic Process RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Exoribonuclease Complex SnRNA 3'-end Processing RNA Metabolic Process RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process 3'-5'-RNA Exonuclease Activity SnRNA Processing Negative Regulation Of Gene Expression RRNA Processing Macromolecule Metabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RNA 3'-end Processing 5'-3' Exonuclease Activity Macromolecule Catabolic Process RNA Processing DNA Deamination Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Exonuclease Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleolus Sno(s)RNA Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing 5'-3' RNA Exonuclease Activity MRNA 3'-UTR AU-rich Region Binding DNA Modification Cysteine-type Deubiquitinase Activity