RINT1 and SNW1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid)

		RINT1	SNW1
Name		RAD50 interactor 1	SNW domain containing 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Dsl1/NZR Complex	Nucleus Nucleoplasm Spliceosomal Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Matrix Nuclear Body Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding	Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Notch Binding Protein Binding Nuclear Receptor Binding Enzyme Binding Nuclear Vitamin D Receptor Binding Nuclear Retinoic Acid Receptor Binding SMAD Binding Nuclear Androgen Receptor Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Mitotic G2 DNA Damage Checkpoint Signaling Protein Transport Vesicle-mediated Transport Regulation Of ER To Golgi Vesicle-mediated Transport	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Host-mediated Activation Of Viral Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Neurogenesis Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid
Pathways		COPI-dependent Golgi-to-ER retrograde traffic	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway mRNA Splicing - Major Pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm
GWAS		No GWAS studies recorded	Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573 )
Interacting Genes		101 interacting genes: AIRIM ANKRD11 ARHGAP45 ARNT2 BFSP2 BLOC1S6 BNIP3L C19orf44 C1orf35 CCDC120 CCDC121 CCDC146 CCDC187 CCDC57 CCDC88B CCHCR1 CDR2L CEP57L1 CSPP1 CWF19L2 DCTN2 DCX DPF2 DRC4 EPC1 ESRRG EXOC8 FAM107A FAM110A FAM124B FAM161A FAM161B FAM81B FAM90A1 FANCG FCHSD2 GFI1B GRAP2 HDAC4 HGS INPP5J JMY KIAA1217 KRT1 LMO2 LSP1P3 LYSMD1 MBD3 MCM7 MISP MYOZ3 NAB2 NFIL3 PCM1 PIK3R2 PIMREG PRPF18 PRPF31 PSTPIP1 RAD50 RAMAC RB1 RBL1 RBL2 RBM41 RIBC1 RNF39 RNF6 RSRC2 RTP5 SCNM1 SFR1 SGF29 SH2D4A SMARCB1 SMARCE1 SNW1 SPTBN1 STRN SUOX TACO1 TEX9 TRIM69 TSEN54 TSHZ2 TSHZ3 TXLNA USHBP1 UTP14C VAV3 VPS37C XPNPEP1 ZBTB16 ZC2HC1C ZNF648 ZNF655 ZNF688 ZNF697 ZNF835 ZSCAN5B ZW10	122 interacting genes: ABLIM3 ACTN2 APOBEC3C AR ASCC2 BAG4 BCAS2 BICD2 BYSL C1orf216 CCDC125 CEBPA CEP55 CEP70 CIRSR CPSF7 CSDE1 CTBP1 CWF19L2 DAXX DMRTB1 EP300 ERCC3 EXOSC5 EXOSC7 EXOSC8 FAM90A1 FTSJ3 GABPB1 GAS2L2 GOLGA2 GRIPAP1 HDAC2 HMBOX1 HOOK1 HOOK2 HSF2BP IKBKG IKZF1 JDP2 KANK2 KRT31 KRT40 LRP2BP LZTS2 MAGEA1 MAGOHB MAPK6 MCMBP MEN1 MFAP1 MISP MSL1 MTUS2 NCK2 NCOA1 NCOR1 NCOR2 NIN NOTCH1 NOTCH3 NR0B1 NR0B2 NXF1 OCLN ODF2 OGT OSTF1 PABPN1 PCBD2 PEG10 PGR PICK1 PPIL1 PRKAA2 PRKAR1B RABEP1 RARA RB1 RBFOX2 RBL1 RBL2 RBM22 RBPJ RBPMS RINT1 RXRA SAAL1 SART1 SIN3A SIRT1 SKI SMAD2 SMAD3 SMAD4 SNU13 SPECC1L STEEP1 SUMO2 TCP11L1 TEX11 TFIP11 THOC1 TNNT1 TOP1 TRAF1 TRAK1 TRIM15 TRIM23 TRIM55 TRIM63 TSNAXIP1 TTC14 TXNL4A USF1 USO1 VAV2 VDR VIM VPS39 WBP4 ZSCAN1
Entrez ID		60561	22938
HPRD ID		15250	04340
Ensembl ID		ENSG00000135249	ENSG00000100603
Uniprot IDs		Q6NUQ1	G3V3A4 Q13573
PDB IDs		Not available	5MQF 5XJC 5YZG 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABF 7ABG 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
GO Terms Enriched among Interactors		Protein Binding Cytoskeleton Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Cytoskeleton Organization Microtubule-based Process Centrosome SWI/SNF Complex Negative Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition NBAF Complex Nuclear Speck Negative Regulation Of Cell Cycle Process Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Double-strand Break Repair Microtubule Anchoring Centriole Protein Localization To Centrosome Regulation Of Sister Chromatid Segregation Cytoskeleton Organization Nucleoplasm Regulation Of Nucleotide-excision Repair Microtubule Binding	Nucleoplasm RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Domain Specific Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription Regulator Complex Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Binding Cytoplasm Chromatin Binding Chromatin Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II RNA Processing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Metabolic Process Rhythmic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process MRNA Splicing, Via Spliceosome