ALX4 and HOXD3

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		ALX4	HOXD3
Name		ALX homeobox 4	homeobox D3
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Aggresome Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal System Development Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Limb Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Digestive Tract Development Neuron Development Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell-matrix Adhesion Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Glossopharyngeal Nerve Morphogenesis Thyroid Gland Development Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Cartilage Development
Pathways		None	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Diseases		Enlarged parietal foramina/cranium bifidum Frontonasal dysplasia	None
GWAS		Blood pressure measurement (high sodium intervention) ( 24165912 ) Brain morphology (MOSTest) ( 32665545 ) Cadmium levels ( 26025379 ) Excessive hairiness ( 29895819 ) ghrelin levels ( 33852427 ) Gout ( 22179738 ) Male-pattern baldness ( 27182965 29146897 ) Monobrow ( 27182965 ) Response to antidepressants in depression ( 29998114 ) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355 )	Estimated glomerular filtration rate ( 31015462 ) Male-pattern baldness ( 28196072 29146897 ) Mucinous ovarian carcinoma ( 26075790 ) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507 ) Ovarian cancer ( 20852632 ) Pelvic organ prolapse (moderate/severe) ( 26545240 )
Interacting Genes		14 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 IQUB LEF1 PARVG SOX10 SOX2	7 interacting genes: ALX4 DDB1 HMGB1 HOXC8 IGFN1 NFKBID SMARCD1
Entrez ID		60529	3232
HPRD ID		05661	00863
Ensembl ID		ENSG00000052850	ENSG00000128652
Uniprot IDs		Q9H161	P31249
PDB IDs		2M0C 8OSB	Not available
GO Terms Enriched among Interactors		Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Regionalization DNA Binding Anterior/posterior Pattern Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Pattern Specification Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Anatomical Structure Morphogenesis Regulation Of RNA Metabolic Process Gland Development Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Skeletal System Morphogenesis Embryonic Morphogenesis Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Skeletal System Morphogenesis Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Regulation Of Macromolecule Biosynthetic Process Embryonic Organ Morphogenesis Glossopharyngeal Nerve Morphogenesis Regulation Of Primary Metabolic Process Developmental Process Animal Organ Development Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Cellular Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Radial Glial Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Cranial Nerve Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Glial Cell Differentiation Nucleus System Development Morphogenesis Of An Epithelium RNA Polymerase II Transcription Regulator Complex	Positive Regulation Of Leukocyte Differentiation Regulation Of Nucleotide-excision Repair Regulation Of Lymphocyte Differentiation Regulation Of T Cell Differentiation Positive Regulation Of Glucose Metabolic Process Epigenetic Regulation Of Gene Expression Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Damaged DNA Binding Positive Regulation Of Viral Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Hemopoiesis Positive Regulation Of Cell Development Regulation Of Glucose Metabolic Process Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Cell Adhesion Negative Regulation Of Apoptotic Cell Clearance Regulation Of Cell-cell Adhesion Regulation Of Viral Life Cycle Regulation Of Lymphocyte Activation Skeletal System Morphogenesis Nucleus Regulation Of Alpha-beta T Cell Activation Positive Regulation Of T Cell Differentiation C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Regulation Of Viral Process Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of DNA Repair Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of Mismatch Repair Regulation Of Cell Activation Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Chromatin Remodeling Positive Regulation Of Small Molecule Metabolic Process Anterior/posterior Pattern Specification Base-excision Repair, AP Site Formation Via Deaminated Base Removal